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AZ7550 hydrochloride
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Catalog No. T13564LCas No. 2309762-40-9
Alias AZ7550 hydrochloride (1421373-99-0 free base)
AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
AZ7550 hydrochloride
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Purity: 99.65%
Catalog No. T13564LAlias AZ7550 hydrochloride (1421373-99-0 free base)Cas No. 2309762-40-9
AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $126 | - | In Stock | |
| 5 mg | $257 | - | In Stock | |
| 10 mg | $397 | - | In Stock | |
| 25 mg | $663 | - | In Stock | |
| 50 mg | $945 | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.65%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM). |
| Targets&IC50 | BLK:977 nM , PYK2:2288 nM , Ack1:156 nM , Insulin receptor:1256 nM , FLT3:302 nM , FAK:995 nM , FES:449 nM , ERB4:195 nM , IGF-1R:1.6 μM , FLT4:1784 nM , MNK2:228 nM , Brk:843 nM , ALK:420 nM , MLK1:88 nM , TEC:1317 nM , IRR:840 nM |
| In vitro | AZ7550 (Compound 28) inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo (IC50s: 45, 26, and 786 nM). AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 (GI50s: 19, 15, and 537 nM). |
| Synonyms | AZ7550 hydrochloride (1421373-99-0 free base) |
| Molecular Weight | 522.04 |
| Formula | C27H32ClN7O2 |
| Cas No. | 2309762-40-9 |
| Smiles | C=CC(NC1=CC(NC2=NC=CC(C3=CN(C4=C3C=CC=C4)C)=N2)=C(C=C1N(CCNC)C)OC)=O.[H]Cl |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | DMSO: 1.5 mg/mL (2.87 mM), Sonication and heating are recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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