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VT103

Catalog No. T62077 CAS 2290608-13-6

Synonyms: VT-103, VT 103

VT103 is an orally active and selective inhibitor of TEAD1 protein palmitoylation and is an analog of VT101. VT103 has potential antitumor activity by inhibiting YAP/TAZ-TEAD-promoted gene transcriptionment, blocking TEAD auto-palmitoylation, and blocking the interaction between YAP/TAZ and TEAD.VT103 can be used in the study of HER2-positive breast cancer, prostate cancer, and triple-negative breast cancer.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

VT103, CAS 2290608-13-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 132.00
5 mg	In stock	$ 328.00
10 mg	In stock	$ 563.00
25 mg	In stock	$ 1,110.00
50 mg	In stock	$ 1,490.00
100 mg	In stock	$ 1,970.00
500 mg	In stock	$ 3,950.00
1 mL * 10 mM (in DMSO)	In stock	$ 363.00

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Purity: 98.73%

Biological Description

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Storage & Solubility Information

Description	VT103 is an orally active and selective inhibitor of TEAD1 protein palmitoylation and is an analog of VT101. VT103 has potential antitumor activity by inhibiting YAP/TAZ-TEAD-promoted gene transcriptionment, blocking TEAD auto-palmitoylation, and blocking the interaction between YAP/TAZ and TEAD.VT103 can be used in the study of HER2-positive breast cancer, prostate cancer, and triple-negative breast cancer.
In vitro	VT103 (3 mmol/L; 4 or 24 h; NF2-deficient NCI-H226 cells) selectively disrupts YAP–TEAD1 interaction.[1] VT103 (3 μM; HEK293T cells) appeared to be TEAD1-selective, as it does not block palmitoylation of TEAD2, TEAD3, or TEAD4.[1] VT103 results in the disappearance of palmitoylated TEAD1 with a concomitant increase in unpalmitoylated TEAD1. VT103 shows an IC50 of 1.02 nM in the YAP reporter assay.[1]
In vivo	VT103 (0.3~10 mg/kg; p.o.; once per day; NCI-H226-tumor-bearing mice) blocks tumor growth even at 0.3 mg/kg[1]. Pharmacokinetics of VT103 in mice.[1]

Synonyms	VT-103, VT 103
Molecular Weight	410.41
Formula	C18H17F3N4O2S
CAS No.	2290608-13-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20.52 mg/mL (50 mM), Sonication is recommended.

References and Literature

1. Tang TT, et al. Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. Mol Cancer Ther. 2021 Jun;20(6):986-998.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Bioactive Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library

Related Products

Related compounds with same targets

AF-2112 TED-347 YAP-TEAD-IN-1 acetate YAP-TEAD-IN-2 TEAD-IN-6 Verteporfin MYF-01-37 AICAR

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

VT103 2290608-13-6 Stem Cells YAP VT-103 VT 103 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.