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Norcholic Acid

Name: Norcholic Acid
Brand: TargetMol
SKU: T37177
Price: 76 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T37177Cas No. 60696-62-0

Alias Nor Cholic Acid

Norcholic Acid (Nor Cholic Acid) is a bile acid that promotes tumor progression and immune escape by modulating the farnesol X receptor in hepatocellular carcinoma.Norcholic Acid is efficiently absorbed from the intestine and is rapidly secreted into the bile.

Norcholic Acid

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Purity: 99.17%

Catalog No. T37177Alias Nor Cholic AcidCas No. 60696-62-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$76	-	In Stock
5 mg	$183	-	In Stock
10 mg	$285	-	In Stock
25 mg	$497	-	In Stock
50 mg	$797	-	In Stock
1 mL x 10 mM (in DMSO)	$480	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.17%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Norcholic Acid (Nor Cholic Acid) is a bile acid that promotes tumor progression and immune escape by modulating the farnesol X receptor in hepatocellular carcinoma.Norcholic Acid is efficiently absorbed from the intestine and is rapidly secreted into the bile.
In vivo	In male Wistar rats (weighing 100-150g), Norcholic acid was administered orally at a concentration of 6.4 g/L, and the results showed that, within the first 24 hours post-administration, an average of approximately 40% of the administered radiolabeled compound could be recovered from the feces[1].
Synonyms	Nor Cholic Acid

Chemical Properties

Molecular Weight	394.54
Formula	C₂₃H₃₈O₅
Cas No.	60696-62-0
Smiles	[H][C@@]1(CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@]12C)[C@H](C)CC(O)=O
Relative Density.	1.201 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Methanol: 10 mg/mL (25.35 mM), Sonication is recommended.

DMSO: 80 mg/mL (202.77 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.36 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Methanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5346 mL	12.6730 mL	25.3460 mL	126.7299 mL
5 mM	0.5069 mL	2.5346 mL	5.0692 mL	25.3460 mL
10 mM	0.2535 mL	1.2673 mL	2.5346 mL	12.6730 mL
20 mM	0.1267 mL	0.6336 mL	1.2673 mL	6.3365 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0507 mL	0.2535 mL	0.5069 mL	2.5346 mL
100 mM	0.0253 mL	0.1267 mL	0.2535 mL	1.2673 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Norcholic Acid