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Norcholic Acid

Name: Norcholic Acid
Brand: TargetMol
SKU: T37177
Price: 118 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T37177Cas No. 60696-62-0

Alias Nor Cholic Acid

Norcholic Acid (Nor Cholic Acid) is a bile acid that promotes tumor progression and immune escape by modulating the farnesol X receptor in hepatocellular carcinoma.Norcholic Acid is efficiently absorbed from the intestine and is rapidly secreted into the bile.

Norcholic Acid

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Purity: 99.17%

Catalog No. T37177Alias Nor Cholic AcidCas No. 60696-62-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$32	-	In Stock
5 mg	$73	-	In Stock
10 mg	$118	-	In Stock
25 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$80	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.17%

Appearance:Solid

Color:White to Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Norcholic Acid (Nor Cholic Acid) is a bile acid that promotes tumor progression and immune escape by modulating the farnesol X receptor in hepatocellular carcinoma.Norcholic Acid is efficiently absorbed from the intestine and is rapidly secreted into the bile.
In vivo	In male Wistar rats (weighing 100-150g), Norcholic acid was administered orally at a concentration of 6.4 g/L, and the results showed that, within the first 24 hours post-administration, an average of approximately 40% of the administered radiolabeled compound could be recovered from the feces[1].
Synonyms	Nor Cholic Acid

Chemical Properties

Molecular Weight	394.54
Formula	C₂₃H₃₈O₅
Cas No.	60696-62-0
Smiles	[H][C@@]1(CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@]12C)[C@H](C)CC(O)=O
Relative Density.	1.201 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Methanol: 10 mg/mL (25.35 mM), Sonication is recommended.

DMSO: 80 mg/mL (202.77 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.36 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Methanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5346 mL	12.6730 mL	25.3460 mL	126.7299 mL
5 mM	0.5069 mL	2.5346 mL	5.0692 mL	25.3460 mL
10 mM	0.2535 mL	1.2673 mL	2.5346 mL	12.6730 mL
20 mM	0.1267 mL	0.6336 mL	1.2673 mL	6.3365 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0507 mL	0.2535 mL	0.5069 mL	2.5346 mL
100 mM	0.0253 mL	0.1267 mL	0.2535 mL	1.2673 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Norcholic Acid