Shopping Cart

Remove All
Your shopping cart is currently empty

Gut restricted-7

Name: Gut restricted-7
Brand: TargetMol
SKU: T11515
Price: 139 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T11515Cas No. 2553218-46-3

Alias GR-7

Gut restricted-7 (GR-7) is a covalent and orally active pan-bile salt hydrolase (BSH) inhibitor that reduces gut bacterial BSHs and decreases deconjugated bile acid levels in the feces of mice.

Gut restricted-7

🥰Excellent

Purity: 99.27%

Catalog No. T11515Alias GR-7Cas No. 2553218-46-3

Gut restricted-7 (GR-7) is a covalent and orally active pan-bile salt hydrolase (BSH) inhibitor that reduces gut bacterial BSHs and decreases deconjugated bile acid levels in the feces of mice.

Pack Size	Price	Availability
1 mg	$139	In Stock
5 mg	$332	In Stock
10 mg	$532	In Stock
25 mg	$863	In Stock
50 mg	$1,190	In Stock
1 mL x 10 mM (in DMSO)	$373	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

Questions

Batch Information

Select Batch

Purity:99.27%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Gut restricted-7 (GR-7) is a covalent and orally active pan-bile salt hydrolase (BSH) inhibitor that reduces gut bacterial BSHs and decreases deconjugated bile acid levels in the feces of mice.
In vitro	Gut restricted-7 (60 μM) does not affect the epithelial barrier integrity of Caco-2 cells, suggesting that this compound is relatively nontoxic. Gut restricted-7 also does not affect microbial biomass.
In vivo	The C57BL/6 mice fed with either powdered chow containing 0.09% Gut restricted-7 (w/w) for 1 d day or powdered chow alone.Gut restricted-7 significant inhibits the BSH activity in the feces of inhibitor-treated mice 8 h post-diet change.20picomol/mg wet mass (~20 μM) of Gut restricted-7 in cecal contents is detected.
Synonyms	GR-7

Chemical Properties

Molecular Weight	510.64
Formula	C₂₅H₄₀FNaO₆S
Cas No.	2553218-46-3
Smiles	O[C@H]1[C@]2([H])[C@@](CC[C@]3([C@@]2([H])CC[C@]3([H])[C@H](C)CCC(CF)=O)C)([H])[C@@]4([C@](C[C@@H](CC4)OS(=O)([O-])=O)([H])C1)C.[Na+]
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (489.59 mM), Sonication is recommended.

H2O: 100 mg/mL (195.83 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (9.79 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9583 mL	9.7916 mL	19.5833 mL	97.9163 mL
5 mM	0.3917 mL	1.9583 mL	3.9167 mL	19.5833 mL
10 mM	0.1958 mL	0.9792 mL	1.9583 mL	9.7916 mL
20 mM	0.0979 mL	0.4896 mL	0.9792 mL	4.8958 mL
50 mM	0.0392 mL	0.1958 mL	0.3917 mL	1.9583 mL
100 mM	0.0196 mL	0.0979 mL	0.1958 mL	0.9792 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc