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GW2974

Name: GW2974
Brand: TargetMol
SKU: T24119
Rating: 4.5 (1 reviews)

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Catalog No. T24119Cas No. 202272-68-2

Alias GW-2974, GW 2974

GW2974 is an orally active dual inhibitor of EGFR and ErbB2 (HER2) with IC50 values of 0.007 μM and 0.016 μM, respectively. It inhibits the invasion of glioblastoma multiforme (GBM) cells and tumor growth in vitro and in vivo.

GW2974

🥰Excellent

Catalog No. T24119Alias GW-2974, GW 2974Cas No. 202272-68-2

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Product Introduction

Bioactivity

Description	GW2974 is an orally active dual inhibitor of EGFR and ErbB2 (HER2) with IC50 values of 0.007 μM and 0.016 μM, respectively. It inhibits the invasion of glioblastoma multiforme (GBM) cells and tumor growth in vitro and in vivo.
Targets&IC50	HER2:0.016 μM, EGFR L858R/T790M:0.007 μM
In vitro	GW2974 (0.001–100 μM, 24 hours) inhibits BT474, HN5, and N87 cell growth [5].
In vivo	Methods: GW2974 was administered at doses of 30 mg/kg and 100 mg/kg to a mouse model of glioblastoma multiforme (GBM) via oral administration once daily. Results: Low-dose GW2974 (30 mg/kg) inhibited intracranial tumor growth, invasion, and angiogenesis, whereas high-dose GW2974 completely reversed the low-dose suppression of tumor invasion [1]. Methods: GW2974 was administered at 10 mg/kg and 30 mg/kg via oral dosing twice daily to HN5 human tumor xenograft mouse models and BT474 human tumor xenograft mouse models. Results: GW2974 significantly inhibited tumor growth in a dose-dependent manner in both models [5].
Synonyms	GW-2974, GW 2974

Chemical Properties

Molecular Weight	395.46
Formula	C₂₃H₂₁N₇
Cas No.	202272-68-2
Smiles	N=1C=NC(NC=2C=CC3=C(C=NN3CC=4C=CC=CC4)C2)=C5C=C(N=CC15)N(C)C
Relative Density.	no data available
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 16 mg/mL (40.46 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5287 mL	12.6435 mL	25.2870 mL	126.4350 mL
5 mM	0.5057 mL	2.5287 mL	5.0574 mL	25.2870 mL
10 mM	0.2529 mL	1.2644 mL	2.5287 mL	12.6435 mL
20 mM	0.1264 mL	0.6322 mL	1.2644 mL	6.3218 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc