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GW2974

Name: GW2974
Brand: TargetMol
SKU: T24119
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24119Cas No. 202272-68-2

Alias GW-2974, GW 2974

GW2974 is an orally active dual inhibitor of EGFR and ErbB2 (HER2) with IC50 values of 0.007 μM and 0.016 μM, respectively. It inhibits the invasion of glioblastoma multiforme (GBM) cells and tumor growth in vitro and in vivo.

GW2974

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Purity: 99.43%

Catalog No. T24119Alias GW-2974, GW 2974Cas No. 202272-68-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$43	-	In Stock
5 mg	$94	-	In Stock
10 mg	$137	-	In Stock
25 mg	$229	-	In Stock
50 mg	$338	-	In Stock
100 mg	$513	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.43%

Appearance:Solid

Color:Yellow

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Product Introduction

Bioactivity

Description	GW2974 is an orally active dual inhibitor of EGFR and ErbB2 (HER2) with IC50 values of 0.007 μM and 0.016 μM, respectively. It inhibits the invasion of glioblastoma multiforme (GBM) cells and tumor growth in vitro and in vivo.
Targets&IC50	HER2:0.016 μM, EGFR L858R/T790M:0.007 μM
In vitro	GW2974 (0.001–100 μM, 24 hours) inhibits BT474, HN5, and N87 cell growth [5].
In vivo	Methods: GW2974 was administered at doses of 30 mg/kg and 100 mg/kg to a mouse model of glioblastoma multiforme (GBM) via oral administration once daily. Results: Low-dose GW2974 (30 mg/kg) inhibited intracranial tumor growth, invasion, and angiogenesis, whereas high-dose GW2974 completely reversed the low-dose suppression of tumor invasion [1]. Methods: GW2974 was administered at 10 mg/kg and 30 mg/kg via oral dosing twice daily to HN5 human tumor xenograft mouse models and BT474 human tumor xenograft mouse models. Results: GW2974 significantly inhibited tumor growth in a dose-dependent manner in both models [5].
Synonyms	GW-2974, GW 2974

Chemical Properties

Molecular Weight	395.46
Formula	C₂₃H₂₁N₇
Cas No.	202272-68-2
Smiles	N=1C=NC(NC=2C=CC3=C(C=NN3CC=4C=CC=CC4)C2)=C5C=C(N=CC15)N(C)C
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 16 mg/mL (40.46 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5287 mL	12.6435 mL	25.2870 mL	126.4350 mL
5 mM	0.5057 mL	2.5287 mL	5.0574 mL	25.2870 mL
10 mM	0.2529 mL	1.2644 mL	2.5287 mL	12.6435 mL
20 mM	0.1264 mL	0.6322 mL	1.2644 mL	6.3218 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc