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PTPN2-IN-2
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Catalog No. T214405 Copy Product Info
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PTPN2-IN-2 is a potent and orally bioavailable PTPN2 inhibitor with an IC50 of 7.05 nM, which enhances the IFN-γ signaling pathway. It also inhibits PTP1B with an IC50 of 9.88 nM. In the B16-OVA mouse model, PTPN2-IN-2 suppresses tumor growth and promotes the activation and infiltration of tumor immune cells. This compound is applicable in melanoma research.
PTPN2-IN-2
Cas No. 3093350-44-5
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | PTPN2-IN-2 is a potent and orally bioavailable PTPN2 inhibitor with an IC50 of 7.05 nM, which enhances the IFN-γ signaling pathway. It also inhibits PTP1B with an IC50 of 9.88 nM. In the B16-OVA mouse model, PTPN2-IN-2 suppresses tumor growth and promotes the activation and infiltration of tumor immune cells. This compound is applicable in melanoma research. |
| Targets & IC50 | PTPN2:7.05 nM |
| In vitro | PTPN2-IN-2 (compound K-38) (0-100 µM; 24 h) enhances the IFN-γ/JAK/STAT1 signaling pathway in Jurkat and B16 cells, indicated by increased STAT1 phosphorylation following IFN-γ stimulation. |
| In vivo | PTPN2-IN-2 (50-150 mg/kg; orally; once daily; for 24 consecutive days) suppresses tumor growth in the B16-OVA mouse model by modulating IFN-γ signal transduction. |
| Molecular Weight | 451.47 |
| Formula | C19H22FN5O5S |
| Cas No. | 3093350-44-5 |
| Smiles | O=C(NC1CCCCCC1)C2=NC=C(N2)C=3C=C(F)C(=C(O)C3)N4CC(=O)NS4(=O)=O |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Related Tags: PTPN2-IN-2 in vivo | PTPN2-IN-2 in vitro | PTPN2-IN-2 formula | PTPN2-IN-2 molecular weight
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