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cGAMP disodium

Catalog No. T13606L CAS 2407516-83-8

cGAMP disodium is a cyclic dinucleotide (CDN) found in bacteria that acts as an endogenous second messenger affecting interferon production in response to cytoplasmic DNA. cGAMP disodium cascades signals from type I interferons and other immune mediators by activating interferon gene stimulator (STING). cGAMP disodium is a potent sublingual immune adjuvant that enables better immune function (serum anti-PA neutralization and airway secretions anti-PA SIgA response).

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cGAMP disodium, CAS 2407516-83-8

Pack Size	Availability	Price/USD	Quantity
100 μg	35 days	$ 265.00
500 μg	35 days	$ 778.00

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Description	cGAMP disodium is a cyclic dinucleotide (CDN) found in bacteria that acts as an endogenous second messenger affecting interferon production in response to cytoplasmic DNA. cGAMP disodium cascades signals from type I interferons and other immune mediators by activating interferon gene stimulator (STING). cGAMP disodium is a potent sublingual immune adjuvant that enables better immune function (serum anti-PA neutralization and airway secretions anti-PA SIgA response).
In vitro	cGAMP disodium directly activates mouse and human dendritic cells in in vitro experiments [1]. It promotes the antigen-specific proliferative capacity of mouse spleen cells [2]. Furthermore, cGAMP disodium induces the induction of antiviral state and the secretion of type I IFNs through activation of the endoplasmic reticulum (ER)-resident receptor STING [3]. cGAMP disodium causes fibroblasts from patients to exhibit increased transcription of IFNB1, which encodes interleukin-1 (IL1), interleukin-6 (IL6) or tumor necrosis factor (TNF) genes did not show a transcriptional increase [4].
In vivo	The titers of OVA specific IgA, total IgG, IgG1 and IgG2c in the serum of female C57BL/6 (H-2b) mice were higher than those of OVA immunized mice after the injection of 5μg at 6-8 weeks of age.

Molecular Weight	720.39
Formula	C20H24N10O13P2.2Na
CAS No.	2407516-83-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Jiaxi Wu, et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 2013 Feb 15;339(6121):826-30. 2. Ivana Škrnjug , et al. Cyclic GMP-AMP displays mucosal adjuvant activity in mice. PLoS One. 2014 Oct 8;9(10):e110150. 3. Andrea Ablasser, et al. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature. 2013 Nov 28;503(7477):530-4.

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Keywords

cGAMP disodium 2407516-83-8 cGAMPdisodium cGAMP inhibitor inhibit

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