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cGAMP disodium

Name: cGAMP disodium
Brand: TargetMol
SKU: T13606L
Rating: 4.5 (1 reviews)

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Catalog No. T13606LCas No. 2407516-83-8

cGAMP disodium is a cyclic dinucleotide (CDN) found in bacteria that acts as an endogenous second messenger affecting interferon production in response to cytoplasmic DNA. cGAMP disodium cascades signals from type I interferons and other immune mediators by activating interferon gene stimulator (STING). cGAMP disodium is a potent sublingual immune adjuvant that enables better immune function (serum anti-PA neutralization and airway secretions anti-PA SIgA response).

cGAMP disodium

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Catalog No. T13606LCas No. 2407516-83-8

Pack Size	Price	USA Warehouse	Global Warehouse
100 μg	$349	35 days	35 days
500 μg	$1,039	35 days	35 days
1 mg	$1,458	Inquiry	Inquiry
5 mg	$2,128	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	cGAMP disodium is a cyclic dinucleotide (CDN) found in bacteria that acts as an endogenous second messenger affecting interferon production in response to cytoplasmic DNA. cGAMP disodium cascades signals from type I interferons and other immune mediators by activating interferon gene stimulator (STING). cGAMP disodium is a potent sublingual immune adjuvant that enables better immune function (serum anti-PA neutralization and airway secretions anti-PA SIgA response).
In vitro	cGAMP disodium directly activates mouse and human dendritic cells in in vitro experiments [1]. It promotes the antigen-specific proliferative capacity of mouse spleen cells [2]. Furthermore, cGAMP disodium induces the induction of antiviral state and the secretion of type I IFNs through activation of the endoplasmic reticulum (ER)-resident receptor STING [3]. cGAMP disodium causes fibroblasts from patients to exhibit increased transcription of IFNB1, which encodes interleukin-1 (IL1), interleukin-6 (IL6) or tumor necrosis factor (TNF) genes did not show a transcriptional increase [4].
In vivo	The titers of OVA specific IgA, total IgG, IgG1 and IgG2c in the serum of female C57BL/6 (H-2b) mice were higher than those of OVA immunized mice after the injection of 5μg at 6-8 weeks of age.

Chemical Properties

Molecular Weight	720.39
Formula	C₂₀H₂₄N₁₀O₁₃P₂.2Na
Cas No.	2407516-83-8
Smiles	O[C@H]1[C@@H](O[C@@]2([H])[C@@]1([H])OP(O)(OC[C@]3([H])[C@@]([C@H]([C@H](N4C5=NC=NC(N)=C5N=C4)O3)O)([H])OP(O)(OC2)=O)=O)N6C7=C(C(N=C(N7)N)=O)N=C6.[Na].[Na]
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc