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Alprenolol hydrochloride

Name: Alprenolol hydrochloride
Brand: TargetMol
SKU: T22236
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22236Cas No. 13707-88-5

Alprenolol hydrochloride is a non-selective blocker of beta, and also is a antagonist of5-HT1A receptor.

Alprenolol hydrochloride

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Purity: 99.79%

Catalog No. T22236Cas No. 13707-88-5

Alprenolol hydrochloride is a non-selective blocker of beta, and also is a antagonist of5-HT1A receptor.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$35	In Stock	In Stock
100 mg	$59	In Stock	In Stock
500 mg	$211	-	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.79%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Alprenolol hydrochloride AI Summary

Alprenolol hydrochloride exhibits a range of bioactivities including significant antiplasmodial activity against various strains of Plasmodium falciparum, with IC50 values between 1995.26 nM and 12589.25 nM after 72 hours as measured by the SYBR green assay. It shows inhibitory effects on a variety of targets: Lamin A splicing, the proliferation of Plasmodium falciparum lines, Human Jumonji Domain Containing 2E (JMJD2E), Tyrosyl-DNA Phosphodiesterase (TDP1), and several histone lysine methyltransferases (G9a). It also modulates Human Peripheral Myelin Protein 22 (PMP22), and inhibits Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1), Polymerase Iota activity, the malarial parasite plastid and its cell entry, Marburg Virus cell entry, Human alpha-Galactosidase at pH 4.5, and Hepatitis C Virus (HCV). Regarding antiviral properties, Alprenolol hydrochloride shows very low activity against SARS-CoV-2 in inhibiting cell viability in Vero E6 cells infected with the strain BavPat1, with an inhibition index of 0.02886 after 72 hours. However, it exhibits some antiviral activity by inhibiting SARS-CoV-2 3CL-Pro protease at 20µM concentration, with an inhibition percentage of 16.74%. Against SARS-CoV-2 induced cytotoxicity, it shows 7.73% inhibition in Caco-2 cells at 10 µM after 48 hours and 0.0% inhibition in Vero-6 cells after similar exposure conditions..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Alprenolol hydrochloride is a non-selective blocker of beta, and also is a antagonist of5-HT1A receptor.

Chemical Properties

Molecular Weight	285.81
Formula	C₁₅H₂₄ClNO₂
Cas No.	13707-88-5
Smiles	Cl.CC(C)NCC(O)COc1ccccc1CC=C
Relative Density.	1.007g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 252.5 mg/mL (883.45 mM), Sonication is recommended.

H2O: 50 mg/mL (174.94 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4988 mL	17.4941 mL	34.9883 mL	174.9414 mL
5 mM	0.6998 mL	3.4988 mL	6.9977 mL	34.9883 mL
10 mM	0.3499 mL	1.7494 mL	3.4988 mL	17.4941 mL
20 mM	0.1749 mL	0.8747 mL	1.7494 mL	8.7471 mL
50 mM	0.0700 mL	0.3499 mL	0.6998 mL	3.4988 mL
100 mM	0.0350 mL	0.1749 mL	0.3499 mL	1.7494 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc