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H-D-Phe-Pip-Arg-pNA dihydrochloride

🥰Excellent
Catalog No. T40711Cas No. 62354-65-8
Alias S-2238 dihydrochloride, H-D-Phe-Pip-Arg-pNA dihydrochloride

H-D-Phe-Pip-Arg-pNA dihydrochloride (S-2238 dihydrochloride), a chromogenic substrate, mimics the N-terminal fragment of the A alpha chain of fibrinogen, the native substrate of thrombin. Specifically designed for thrombin detection, it is employed for quantifying antithrombin-heparin cofactor (AT-III) and is characterized by its sensitivity, accuracy, and ease of implementation.

H-D-Phe-Pip-Arg-pNA dihydrochloride
Other Forms of H-D-Phe-Pip-Arg-pNA dihydrochloride:
H-D-Phe-Pip-Arg-pNAT3446264815-81-2
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H-D-Phe-Pip-Arg-pNA dihydrochloride

🥰Excellent
Purity: 99.47%
Catalog No. T40711Alias S-2238 dihydrochloride, H-D-Phe-Pip-Arg-pNA dihydrochlorideCas No. 62354-65-8
H-D-Phe-Pip-Arg-pNA dihydrochloride (S-2238 dihydrochloride), a chromogenic substrate, mimics the N-terminal fragment of the A alpha chain of fibrinogen, the native substrate of thrombin. Specifically designed for thrombin detection, it is employed for quantifying antithrombin-heparin cofactor (AT-III) and is characterized by its sensitivity, accuracy, and ease of implementation.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$179In StockIn Stock
5 mg$365In StockIn Stock
10 mg$543In StockIn Stock
25 mg$877In StockIn Stock
50 mg$1,180In StockIn Stock
100 mg$1,620-In Stock
1 mL x 10 mM (in DMSO)$689In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.47%
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Product Introduction

Bioactivity
Description
H-D-Phe-Pip-Arg-pNA dihydrochloride (S-2238 dihydrochloride), a chromogenic substrate, mimics the N-terminal fragment of the A alpha chain of fibrinogen, the native substrate of thrombin. Specifically designed for thrombin detection, it is employed for quantifying antithrombin-heparin cofactor (AT-III) and is characterized by its sensitivity, accuracy, and ease of implementation.
SynonymsS-2238 dihydrochloride, H-D-Phe-Pip-Arg-pNA dihydrochloride
Chemical Properties
Molecular Weight625.55
FormulaC27H38Cl2N8O5
Cas No.62354-65-8
SmilesN=C(N)NCCC[C@@H](C(NC(C1NCCCC1)=O)=O)N(C([C@@H](CC2=CC=CC=C2)N)=O)C3=CC=C([N+]([O-])=O)C=C3.[H]Cl.[H]Cl
SequenceH-D-Phe-Pip-Arg-pNA.
Sequence ShortFXR
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 125 mg/mL (199.82 mM), Sonication is recommended.
DMSO: 125 mg/mL (199.82 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (6.39 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM1.5986 mL7.9930 mL15.9859 mL79.9297 mL
5 mM0.3197 mL1.5986 mL3.1972 mL15.9859 mL
10 mM0.1599 mL0.7993 mL1.5986 mL7.9930 mL
20 mM0.0799 mL0.3996 mL0.7993 mL3.9965 mL
50 mM0.0320 mL0.1599 mL0.3197 mL1.5986 mL
100 mM0.0160 mL0.0799 mL0.1599 mL0.7993 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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Keywords

thrombinsubstrateS-2238 DihydrochlorideS2238 DihydrochlorideS-2238S2238S 2238 DihydrochlorideS 2238InhibitorinhibitH-D-Phe-Pip-Arg-pNA DihydrochlorideHDPhePipArgpNA dihydrochlorideH-D-Phe-Pip-Arg-pNAH D Phe Pip Arg pNA dihydrochloridefibrinogencofactorchromogenicAT-IIIantithrombin-heparin
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