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H-D-Phe-Pip-Arg-pNA dihydrochloride

Name: H-D-Phe-Pip-Arg-pNA dihydrochloride
Brand: TargetMol
SKU: T40711
Price: 179 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T40711Cas No. 62354-65-8

Alias S-2238 dihydrochloride, H-D-Phe-Pip-Arg-pNA dihydrochloride

H-D-Phe-Pip-Arg-pNA dihydrochloride (S-2238 dihydrochloride), a chromogenic substrate, mimics the N-terminal fragment of the A alpha chain of fibrinogen, the native substrate of thrombin. Specifically designed for thrombin detection, it is employed for quantifying antithrombin-heparin cofactor (AT-III) and is characterized by its sensitivity, accuracy, and ease of implementation.

H-D-Phe-Pip-Arg-pNA dihydrochloride

🥰Excellent

Purity: 99.47%

Catalog No. T40711Alias S-2238 dihydrochloride, H-D-Phe-Pip-Arg-pNA dihydrochlorideCas No. 62354-65-8

Pack Size	Price	Availability
1 mg	$179	In Stock
5 mg	$365	In Stock
10 mg	$543	In Stock
25 mg	$877	In Stock
50 mg	$1,180	In Stock
100 mg	$1,620	In Stock
1 mL x 10 mM (in DMSO)	$689	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.47%

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COA HPLC

Product Introduction

Bioactivity

Description	H-D-Phe-Pip-Arg-pNA dihydrochloride (S-2238 dihydrochloride), a chromogenic substrate, mimics the N-terminal fragment of the A alpha chain of fibrinogen, the native substrate of thrombin. Specifically designed for thrombin detection, it is employed for quantifying antithrombin-heparin cofactor (AT-III) and is characterized by its sensitivity, accuracy, and ease of implementation.
Synonyms	S-2238 dihydrochloride, H-D-Phe-Pip-Arg-pNA dihydrochloride

Chemical Properties

Molecular Weight	625.55
Formula	C₂₇H₃₈Cl₂N₈O₅
Cas No.	62354-65-8
Smiles	N=C(N)NCCC[C@@H](C(NC(C1NCCCC1)=O)=O)N(C([C@@H](CC2=CC=CC=C2)N)=O)C3=CC=C([N+]([O-])=O)C=C3.[H]Cl.[H]Cl
Sequence	H-D-Phe-Pip-Arg-pNA.
Sequence Short	FXR

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 125 mg/mL (199.82 mM), Sonication is recommended.

DMSO: 125 mg/mL (199.82 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5986 mL	7.9930 mL	15.9859 mL	79.9297 mL
5 mM	0.3197 mL	1.5986 mL	3.1972 mL	15.9859 mL
10 mM	0.1599 mL	0.7993 mL	1.5986 mL	7.9930 mL
20 mM	0.0799 mL	0.3996 mL	0.7993 mL	3.9965 mL
50 mM	0.0320 mL	0.1599 mL	0.3197 mL	1.5986 mL
100 mM	0.0160 mL	0.0799 mL	0.1599 mL	0.7993 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

thrombinsubstrateS-2238 DihydrochlorideS2238 DihydrochlorideS-2238S2238S 2238 DihydrochlorideS 2238InhibitorinhibitH-D-Phe-Pip-Arg-pNA DihydrochlorideHDPhePipArgpNA dihydrochlorideH-D-Phe-Pip-Arg-pNAH D Phe Pip Arg pNA dihydrochloridefibrinogencofactorchromogenicAT-IIIantithrombin-heparin

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