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Anti-p16-INK4a Antibody (7Y998)
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Catalog No. TMAC-02938
Alias p19ARF, p16-INK4a, p16-INK4, p16Cdkn2a, p16, MTS1, INK4A, cyclin-dependent kinase inhibitor 2A, isoform 2, cyclin-dependent kinase inhibitor 2A, isoform 1, cyclin-dependent kinase inhibitor 2a p19Arf, cyclin-dependent kinase inhibitor 2a p16Ink4a, cyclin-dependent kinase inhibitor 2A, cyclin-dependent kinase 4 inhibitor A, Cyclin dependent kinase inhibitor 2A(p16, inhibits CDK4), cell cycle regulator, cell cycle inhibitor, Cdkn2a, CDK4I, CD2A2, Arf
Anti-p16-INK4a Antibody (7Y998) is a Rabbit antibody targeting p16-INK4a. Anti-p16-INK4a Antibody (7Y998) can be used in WB,ICC/IF,IHC,IP,FCM.
Anti-p16-INK4a Antibody (7Y998)
Anti-p16-INK4a Antibody (7Y998)
😃Good
Catalog No. TMAC-02938Alias p19ARF, p16-INK4a, p16-INK4, p16Cdkn2a, p16, MTS1, INK4A, cyclin-dependent kinase inhibitor 2A, isoform 2, cyclin-dependent kinase inhibitor 2A, isoform 1, cyclin-dependent kinase inhibitor 2a p19Arf, cyclin-dependent kinase inhibitor 2a p16Ink4a, cyclin-dependent kinase inhibitor 2A, cyclin-dependent kinase 4 inhibitor A, Cyclin dependent kinase inhibitor 2A(p16, inhibits CDK4), cell cycle regulator, cell cycle inhibitor, Cdkn2a, CDK4I, CD2A2, Arf
Anti-p16-INK4a Antibody (7Y998) is a Rabbit antibody targeting p16-INK4a. Anti-p16-INK4a Antibody (7Y998) can be used in WB,ICC/IF,IHC,IP,FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $298 | 7-10 days | |
| 100 μL | $497 | 7-10 days |
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| Description | Anti-p16-INK4a Antibody (7Y998) is a Rabbit antibody targeting p16-INK4a. Anti-p16-INK4a Antibody (7Y998) can be used in WB,ICC/IF,IHC,IP,FCM. |
| Synonyms | p19ARF, p16-INK4a, p16-INK4, p16Cdkn2a, p16, MTS1, INK4A, cyclin-dependent kinase inhibitor 2A, isoform 2, cyclin-dependent kinase inhibitor 2A, isoform 1, cyclin-dependent kinase inhibitor 2a p19Arf, cyclin-dependent kinase inhibitor 2a p16Ink4a, cyclin-dependent kinase inhibitor 2A, cyclin-dependent kinase 4 inhibitor A, Cyclin dependent kinase inhibitor 2A(p16, inhibits CDK4), cell cycle regulator, cell cycle inhibitor, Cdkn2a, CDK4I, CD2A2, Arf |
| Ig Type | IgG |
| Reactivity | Human |
| Verified Activity | 1. Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-p16INK4A antibody. Counter stained with hematoxylin. 2. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-p16INK4A antibody. Counter stained with hematoxylin. 3. ICC staining p16INK4A in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 4. ICC staining p16INK4A in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 5. ICC staining p16INK4A in PC-3M cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 6. Flow cytometric analysis of Hela cells with p16INK4A antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody. |
| Application | |
| Recommended Dose | WB: 1:500-1000; IHC: 1:50-200; ICC/IF: 1:100-500; FCM: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | The progression of cells through the cell cycle is regulated by a family of proteins designated cyclin-dependent kinases (Cdks). Sequential activation of individual members of this family and their consequent phosphorylation of critical substrates, promote orderly progression through the cell cycle. The protein p16INK4A, identified as a negative regulator of the cell cycle, has been shown to bind to and inhibit the activity of the Cdk4/cyclin D complex. p19 ARF, which is unrelated to p16, arises from transcription of an alternative reading frame of the p16 gene. Like p16, p19 ARF has been shown to induce cell cycle arrest. Mice lacking p19 ARF but expressing functional p16 have been shown to develop tumors early in life. Further studies have indicated that p19 ARF may be disrupted in a large percentage of human T cell acute lymphoblastic leukemias. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 17 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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