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14,15-EE-5(Z)-E

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Catalog No. T36150Cas No. 519038-92-7

Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity. 14,15-EE-5(Z)-E is a structural analog of 14,15-epoxyeicosatrienoic acids (14,15-EET) that antagonizes EET-induced relaxation of vascular smooth muscle. Relaxation of U46619-constricted bovine arteries by 14,15-EET could be inhibited approximately 80% by 14,15-EE-5(Z)-E at a concentration of 10 μM. 14,15-EE-5(Z)-E does not appear to antagonize nitric oxide- or iloprost-mediated vascular relaxation.

14,15-EE-5(Z)-E

14,15-EE-5(Z)-E

😃Good
Catalog No. T36150Cas No. 519038-92-7
Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity. 14,15-EE-5(Z)-E is a structural analog of 14,15-epoxyeicosatrienoic acids (14,15-EET) that antagonizes EET-induced relaxation of vascular smooth muscle. Relaxation of U46619-constricted bovine arteries by 14,15-EET could be inhibited approximately 80% by 14,15-EE-5(Z)-E at a concentration of 10 μM. 14,15-EE-5(Z)-E does not appear to antagonize nitric oxide- or iloprost-mediated vascular relaxation.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 μg$15935 days35 days
50 μg$29735 days35 days
100 μg$56235 days35 days
500 μg$2,46035 days35 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity. 14,15-EE-5(Z)-E is a structural analog of 14,15-epoxyeicosatrienoic acids (14,15-EET) that antagonizes EET-induced relaxation of vascular smooth muscle. Relaxation of U46619-constricted bovine arteries by 14,15-EET could be inhibited approximately 80% by 14,15-EE-5(Z)-E at a concentration of 10 μM. 14,15-EE-5(Z)-E does not appear to antagonize nitric oxide- or iloprost-mediated vascular relaxation.
Chemical Properties
Molecular Weight324.505
FormulaC20H36O3
Cas No.519038-92-7
Relative Density.0.957 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMF: 10 mg/mL (30.82 mM), Sonication is recommended.
PBS (pH 7.2): 0.5 mg/mL (1.54 mM), Sonication is recommended.
DMSO: 10 mg/mL (30.82 mM), Sonication is recommended.
Ethanol: 50 mg/mL (154.08 mM), Sonication is recommended.
Solution Preparation Table
PBS (pH 7.2)/DMF/DMSO/Ethanol
1mg5mg10mg50mg
1 mM3.0816 mL15.4081 mL30.8162 mL154.0808 mL
DMF/DMSO/Ethanol
1mg5mg10mg50mg
5 mM0.6163 mL3.0816 mL6.1632 mL30.8162 mL
10 mM0.3082 mL1.5408 mL3.0816 mL15.4081 mL
20 mM0.1541 mL0.7704 mL1.5408 mL7.7040 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

14,15-EE-5E14,15EE5(Z)E14,15 EE 5(Z) E
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