Shopping Cart
- Remove All
- Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $59 | In Stock | |
5 mg | $142 | In Stock | |
10 mg | $229 | In Stock | |
25 mg | $383 | In Stock | |
50 mg | $548 | In Stock | |
100 mg | $738 | In Stock | |
200 mg | $993 | In Stock |
Description | ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 can induce anti-proliferative effects and apoptosis. |
Targets&IC50 | SMARCA2:6 nM (DC50), SMARCA4:11 nM (DC50), PBRM1:32 nM (DC50) |
Molecular Weight | 936.1 |
Formula | C49H58FN9O7S |
Cas No. | 2375564-55-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (106.83 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.