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ACBI1

ACBI1
ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 can induce anti-proliferative effects and apoptosis.
Catalog No. T17350Cas No. 2375564-55-7
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Purity:98.15%
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ACBI1

Catalog No. T17350Cas No. 2375564-55-7

ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 can induce anti-proliferative effects and apoptosis.
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Pack SizePriceAvailabilityQuantity
1 mg$59In Stock
5 mg$142In Stock
10 mg$229In Stock
25 mg$383In Stock
50 mg$548In Stock
100 mg$738In Stock
200 mg$993In Stock
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Product Introduction

Bioactivity
Description
ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 can induce anti-proliferative effects and apoptosis.
Targets&IC50
SMARCA2:6 nM (DC50), SMARCA4:11 nM (DC50), PBRM1:32 nM (DC50)
Chemical Properties
Molecular Weight936.1
FormulaC49H58FN9O7S
Cas No.2375564-55-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (106.83 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.0683 mL5.3413 mL10.6826 mL53.4131 mL
5 mM0.2137 mL1.0683 mL2.1365 mL10.6826 mL
10 mM0.1068 mL0.5341 mL1.0683 mL5.3413 mL
20 mM0.0534 mL0.2671 mL0.5341 mL2.6707 mL
50 mM0.0214 mL0.1068 mL0.2137 mL1.0683 mL
100 mM0.0107 mL0.0534 mL0.1068 mL0.5341 mL

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