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Tetrabenazine Metabolite

Name: Tetrabenazine Metabolite
Brand: TargetMol
SKU: T13133
Price: 70 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13133Cas No. 924854-60-4

Alias (-)-β-HTBZ, (-)-β-Dihydrotetrabenazine

Tetrabenazine Metabolite ((-)-β-HTBZ), a vesicles monoamine transporter 2 (VMAT2) inhibitor, is an active metabolite of Tetrabenazine. Tetrabenazine Metabolite has a high affinity for VMAT2 with a Ki of 13.4 nM. Tetrabenazine Metabolite is often used to study chorea associated with Huntington's disease and other hyperactivity disorders.

Tetrabenazine Metabolite

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Purity: 97.09%

Catalog No. T13133Alias (-)-β-HTBZ, (-)-β-DihydrotetrabenazineCas No. 924854-60-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$70	In Stock	In Stock
5 mg	$161	In Stock	In Stock
10 mg	$236	In Stock	In Stock
25 mg	$355	In Stock	In Stock
50 mg	$497	In Stock	In Stock
100 mg	$678	In Stock	In Stock
200 mg	$913	-	In Stock
1 mL x 10 mM (in DMSO)	$157	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.09%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Tetrabenazine Metabolite ((-)-β-HTBZ), a vesicles monoamine transporter 2 (VMAT2) inhibitor, is an active metabolite of Tetrabenazine. Tetrabenazine Metabolite has a high affinity for VMAT2 with a Ki of 13.4 nM. Tetrabenazine Metabolite is often used to study chorea associated with Huntington's disease and other hyperactivity disorders.
Targets&IC50	VMAT2:13.4 nM
Synonyms	(-)-β-HTBZ, (-)-β-Dihydrotetrabenazine

Chemical Properties

Molecular Weight	319.44
Formula	C₁₉H₂₉NO₃
Cas No.	924854-60-4
Smiles	[H][C@]12C[C@H](O)[C@H](CC(C)C)CN1CCc1cc(OC)c(OC)cc21
Relative Density.	1.13±0.1 g/cm3 (20 °C, 760 mmHg)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 32.5 mg/mL (101.74 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1305 mL	15.6524 mL	31.3048 mL	156.5239 mL
5 mM	0.6261 mL	3.1305 mL	6.2610 mL	31.3048 mL
10 mM	0.3130 mL	1.5652 mL	3.1305 mL	15.6524 mL
20 mM	0.1565 mL	0.7826 mL	1.5652 mL	7.8262 mL
50 mM	0.0626 mL	0.3130 mL	0.6261 mL	3.1305 mL
100 mM	0.0313 mL	0.1565 mL	0.3130 mL	1.5652 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc