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Keap1-Nrf2-IN-28

Name: Keap1-Nrf2-IN-28
Brand: TargetMol
SKU: T207165
Rating: 4.5 (1 reviews)

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Catalog No. T207165Cas No. 3075750-60-3

Keap1-Nrf2-IN-28 (SG16) is an orally active inhibitor of Keap1-Nrf2. It demonstrates antioxidant properties and upregulates the expression of Nrf2, HO-1, GCLM, and Akr1c1. Additionally, Keap1-Nrf2-IN-28 can mitigate acute liver injury induced by APAP.

Keap1-Nrf2-IN-28

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Catalog No. T207165Cas No. 3075750-60-3

Pack Size	Price	Availability	Quantity
10 mg	Inquiry	10-14 weeks
50 mg	Inquiry	10-14 weeks

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Keap1-Nrf2-IN-28 (SG16) is an orally active inhibitor of Keap1-Nrf2. It demonstrates antioxidant properties and upregulates the expression of Nrf2, HO-1, GCLM, and Akr1c1. Additionally, Keap1-Nrf2-IN-28 can mitigate acute liver injury induced by APAP.
In vitro	Keap1-Nrf2-IN-28 (Compound SG16) at a concentration of 10 μM for 16 hours significantly induces a 10.7-fold increase in HO-1 expression in AML12 cells, demonstrating its Nrf2 induction capability. Additionally, Keap1-Nrf2-IN-28 (0-10 μM, 16 hours) enhances the mRNA expression of HO-1, GCLM, and Akr1c1, as well as the protein expression of Nrf2, HO-1, and GCLM in AML12 cells.
In vivo	Keap1-Nrf2-IN-28 (Compound SG16), administered intraperitoneally at doses of 12.5 or 25 mg/kg, can protect mice from acute liver injury (ALI) induced by APAP. At 25 mg/kg, intraperitoneally, it shows no liver protective effects in Nrf2 knockout mice. When given at 25 mg/kg to C57BL/6J mice, Keap1-Nrf2-IN-28 demonstrates good biocompatibility with no observed organ toxicity.

Chemical Properties

Molecular Weight	425.43
Formula	C₂₂H₁₆FNO₅S
Cas No.	3075750-60-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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