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CVT-12012

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Catalog No. T6412Cas No. 1018675-35-8

CVT-12012 is an orally bioavailable inhibitor of stearoyl-CoA desaturase (SCD; IC50 = 6.1 nM in HepG2 cells).

CVT-12012

CVT-12012

🥰Excellent
Purity: 99.56%
Catalog No. T6412Cas No. 1018675-35-8
CVT-12012 is an orally bioavailable inhibitor of stearoyl-CoA desaturase (SCD; IC50 = 6.1 nM in HepG2 cells).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$34In StockIn Stock
5 mg$80In StockIn Stock
10 mg$122In StockIn Stock
25 mg$222In StockIn Stock
50 mg$333In StockIn Stock
100 mg$496In StockIn Stock
1 mL x 10 mM (in DMSO)$89In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.56%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
CVT-12012 is an orally bioavailable inhibitor of stearoyl-CoA desaturase (SCD; IC50 = 6.1 nM in HepG2 cells).
Targets&IC50
HepG2 cells:6.1 nM, Microsomal (rat):38 nM
In vivo
CVT-12012 is highly potent in a human cell-based (HEPG2) SCD assay (IC(50)=6nM). This compound has 78% oral bioavailability in rats and is preferentially distributed into liver (76 times vs plasma) with relatively low brain penetration[1].
Chemical Properties
Molecular Weight434.41
FormulaC21H21F3N4O3
Cas No.1018675-35-8
SmilesCc1nc2ccc(NCc3cccc(c3)C(F)(F)F)cc2n(CCNC(=O)CO)c1=O
Relative Density.1.37 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 125 mg/mL (287.75 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (9.21 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3020 mL11.5099 mL23.0197 mL115.0986 mL
5 mM0.4604 mL2.3020 mL4.6039 mL23.0197 mL
10 mM0.2302 mL1.1510 mL2.3020 mL11.5099 mL
20 mM0.1151 mL0.5755 mL1.1510 mL5.7549 mL
50 mM0.0460 mL0.2302 mL0.4604 mL2.3020 mL
100 mM0.0230 mL0.1151 mL0.2302 mL1.1510 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

StearoylCoADesaturase(SCD)StearoylCoADesaturaseStearoyl-CoA Desaturase (SCD)StearoylCoA Desaturase (SCD)Stearoyl-CoA DesaturaseSCDrat microsomalInhibitorinhibithuman HEPG2CVT-12012CVT12012CVT 12012
Related Tags: buy CVT-12012 | purchase CVT-12012 | CVT-12012 cost | order CVT-12012 | CVT-12012 chemical structure | CVT-12012 in vivo | CVT-12012 formula | CVT-12012 molecular weight
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