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Indantadol HCl

Name: Indantadol HCl
Brand: TargetMol
SKU: T27606
Price: 117 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T27606Cas No. 202914-18-9

Alias Indantadol hydrochloride, CHF-3381

Indantadol HCl (CHF-3381) is a NMDA antagonist and nonselective MAO inhibitor.

Indantadol HCl

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Purity: 99.56%

Catalog No. T27606Alias Indantadol hydrochloride, CHF-3381Cas No. 202914-18-9

Indantadol HCl (CHF-3381) is a NMDA antagonist and nonselective MAO inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$117	-	In Stock
5 mg	$258	-	In Stock
10 mg	$382	-	In Stock
25 mg	$592	-	In Stock
50 mg	$816	-	In Stock
100 mg	$1,090	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.56%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Indantadol HCl (CHF-3381) is a NMDA antagonist and nonselective MAO inhibitor.
In vivo	In a human heat-capsaicin-induced pain model, Indantadol HCl at a dose of 500 mg effectively reduced the area of secondary hyperalgesia to 67%. Indantadol HCl undergoes extensive liver metabolism, withthe formation of two major metabolites - CHF-3567 and 2-aminoindane. The drug is excreted in urine partially as the parent compound, but mostly as CHF-3567. The tolerability profile of Indantadol HCl at single doses up to 600 mg and twice-daily doses up to 400 mg in clinical trials was significantly more favorable than for other NMDA antagonists. Most side effects have been observed to be mild, and include dizziness and asthenia. Indantadol HCl is currently in phase II clinical trials in patients with diabetic peripheral neuropathic pain.[1]
Synonyms	Indantadol hydrochloride, CHF-3381

Chemical Properties

Molecular Weight	226.7
Formula	C₁₁H₁₅ClN₂O
Cas No.	202914-18-9
Smiles	Cl.O=C(N)CNC1CC=2C=CC=CC2C1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (220.56 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4111 mL	22.0556 mL	44.1112 mL	220.5558 mL
5 mM	0.8822 mL	4.4111 mL	8.8222 mL	44.1112 mL
10 mM	0.4411 mL	2.2056 mL	4.4111 mL	22.0556 mL
20 mM	0.2206 mL	1.1028 mL	2.2056 mL	11.0278 mL
50 mM	0.0882 mL	0.4411 mL	0.8822 mL	4.4111 mL
100 mM	0.0441 mL	0.2206 mL	0.4411 mL	2.2056 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc