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NSC622608

🥰Excellent
Catalog No. T35362Cas No. 2593254-90-9

NSC622608 is a small-molecule ligand for V-domain Ig suppressor of T-cell activation (VISTA) which is an immune checkpoint that affects the ability of T-cells to attack tumors.

NSC622608

NSC622608

🥰Excellent
Purity: 98.48%
Catalog No. T35362Cas No. 2593254-90-9
NSC622608 is a small-molecule ligand for V-domain Ig suppressor of T-cell activation (VISTA) which is an immune checkpoint that affects the ability of T-cells to attack tumors.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$38In StockIn Stock
5 mg$89In StockIn Stock
10 mg$155In StockIn Stock
25 mg$313In StockIn Stock
50 mg$472In StockIn Stock
100 mg$678In StockIn Stock
1 mL x 10 mM (in DMSO)$119In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.48%
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Product Introduction

Bioactivity
Description
NSC622608 is a small-molecule ligand for V-domain Ig suppressor of T-cell activation (VISTA) which is an immune checkpoint that affects the ability of T-cells to attack tumors.
In vitro
NSC622608 blocked VISTA signaling in vitro, enhanced T-cell proliferation, and restored T-cell activation in the presence of VISTA-expressing cancer cell lines[1].
Chemical Properties
Molecular Weight322.24
FormulaC9H12BrN3OS2
Cas No.2593254-90-9
SmilesBr.CN(C)c1n\c(=N\Cc2ccco2)ss1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 4.67 mg/mL (14.49 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.1033 mL15.5164 mL31.0328 mL155.1639 mL
5 mM0.6207 mL3.1033 mL6.2066 mL31.0328 mL
10 mM0.3103 mL1.5516 mL3.1033 mL15.5164 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

VISTAV-domain Ig suppressor of T-cell activation (VISTA)NSC-622608NSC622608NSC 622608Inhibitorinhibit
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