Dot1L-IN-2

Name: Dot1L-IN-2
Brand: TargetMol
SKU: T11082
Rating: 4.5 (1 reviews)

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Catalog No. T11082Cas No. 1940206-71-2

Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectively.

Dot1L-IN-2

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Catalog No. T11082Cas No. 1940206-71-2

Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectively.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,670	6-8 weeks	6-8 weeks
50 mg	$2,180	6-8 weeks	6-8 weeks
100 mg	$2,800	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectively.
Targets&IC50	DOT1L:(ki)0.08 nM , DOT1L:0.4 nM
In vitro	Dot1l-in-2 is an effective and selective Dot1L inhibitor with IC50 and Ki of 0.4 nM and 0.08 nM, respectively.Dot1l-in-2 effectively inhibits H3K79 dimethylation (IC50, 16 nM) and blocks the activity of the HoxA9 promoter (IC50, 340 nM) IN the cellular system.Dot1l-in-2 also significantly inhibited the proliferation of human mll-recombinant leukemia cell line mv4-11 carrying carcinogenic mll-af4 fusion (IC50, 128nm).

Chemical Properties

Molecular Weight	476.53
Formula	C₂₇H₂₄N₈O
Cas No.	1940206-71-2
Relative Density.	1.36 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

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