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PACOCF3

Catalog No. T21907 CAS 141022-99-3

Synonyms: 1,1,1-trifluoroheptadecan-2-one, Palmityltrifluoromethylketone

PACOCF3 (Palmityltrifluoromethylketone) (Palmityltrifluoromet hylketone) is an inhibitor of Ca(2+)-independent phospholipase A2(PLA2) with an IC 50 of 3.8 μM. PACOCF3 alters Ca 2+ signaling in renal tubular cells [1] [2].

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PACOCF3, CAS 141022-99-3

Pack Size	Availability	Price/USD
5 mg	In stock	$ 39.00
10 mg	In stock	$ 55.00
25 mg	In stock	$ 98.00
50 mg	In stock	$ 168.00
100 mg	In stock	$ 272.00
200 mg	In stock	$ 396.00

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Purity: 99.57%

Biological Description

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Storage & Solubility Information

Description

In vitro

PACOCF3 does not affect basal cytosolic free calcium concentrations ([Ca2+]i) at 20 μM, but a dosage between 50-250 μM triggers an increase in [Ca2+]i through the stimulation of extracellular Ca2+ entry, which can be partially inhibited by 50 μM La3+[2]. This PACOCF3-induced effect is negated when extracellular Ca2+ is removed. At a concentration of 10 μM, PACOCF3 amplifies the peak and the area under the curve of the [Ca2+]i surge elicited by 10 μM ATP and 1 μM bradykinin, by enhancing extracellular Ca2+ influx without altering internal Ca2+ release[2].

Synonyms	1,1,1-trifluoroheptadecan-2-one, Palmityltrifluoromethylketone
Molecular Weight	308.42
Formula	C17H31F3O
CAS No.	141022-99-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 31.5 mg/mL (102.1 mM), Sonication is recommended.

References and Literature

1. E J Ackermann, et al. Inhibition of macrophage Ca(2+)-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones. J Biol Chem. 1995 Jan 6;270(1):445-50. 2. C R Jan, et al. Dual action of palmitoyl trifluoromethyl ketone (PACOCF3) on Ca2+ signaling: activation of extracellular Ca2+ influx and alteration of ATP- and bradykinin-induced Ca2+ responses in Madin Darby canine kidney cells. Arch Toxicol. 2000 Oct;74.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

Amentoflavone Omeprazole ML299 Lp-PLA2-IN-1 5α-Hydroxycostic acid nSMase2-IN-1 AA26-9 Melittin TFA(20449-79-0(free base))

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PACOCF3 141022-99-3 Metabolism Phospholipase 1,1,1-trifluoroheptadecan-2-one Palmityltrifluoromethylketone PACOCF-3 Palmityltrifluoromethylketone PACOCF 3 inhibitor inhibit

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