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PACOCF3

Name: PACOCF3
Brand: TargetMol
SKU: T21907
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21907Cas No. 141022-99-3

Alias Palmityltrifluoromethylketone, 1,1,1-trifluoroheptadecan-2-one

PACOCF3 (Palmityltrifluoromethylketone) (Palmityltrifluoromet hylketone) is an inhibitor of Ca(2+)-independent phospholipase A2(PLA2) with an IC 50 of 3.8 μM. PACOCF3 alters Ca 2+ signaling in renal tubular cells [1] [2].

PACOCF3

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Purity: 99.93%

Catalog No. T21907Alias Palmityltrifluoromethylketone, 1,1,1-trifluoroheptadecan-2-oneCas No. 141022-99-3

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$39	-	In Stock
10 mg	$55	-	In Stock
25 mg	$98	-	In Stock
50 mg	$168	-	In Stock
100 mg	$272	-	In Stock
200 mg	$396	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.93%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	PACOCF3 (Palmityltrifluoromethylketone) (Palmityltrifluoromet hylketone) is an inhibitor of Ca(2+)-independent phospholipase A2(PLA2) with an IC 50 of 3.8 μM. PACOCF3 alters Ca 2+ signaling in renal tubular cells [1] [2].
Targets&IC50	PLA2:3.8 μM
In vitro	PACOCF3 does not affect basal cytosolic free calcium concentrations ([Ca2+]i) at 20 μM, but a dosage between 50-250 μM triggers an increase in [Ca2+]i through the stimulation of extracellular Ca2+ entry, which can be partially inhibited by 50 μM La3+[2]. This PACOCF3-induced effect is negated when extracellular Ca2+ is removed. At a concentration of 10 μM, PACOCF3 amplifies the peak and the area under the curve of the [Ca2+]i surge elicited by 10 μM ATP and 1 μM bradykinin, by enhancing extracellular Ca2+ influx without altering internal Ca2+ release[2].
Synonyms	Palmityltrifluoromethylketone, 1,1,1-trifluoroheptadecan-2-one

Chemical Properties

Molecular Weight	308.42
Formula	C₁₇H₃₁F₃O
Cas No.	141022-99-3
Smiles	CCCCCCCCCCCCCCCC(=O)C(F)(F)F
Relative Density.	0.955 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (145.9 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2423 mL	16.2117 mL	32.4233 mL	162.1166 mL
5 mM	0.6485 mL	3.2423 mL	6.4847 mL	32.4233 mL
10 mM	0.3242 mL	1.6212 mL	3.2423 mL	16.2117 mL
20 mM	0.1621 mL	0.8106 mL	1.6212 mL	8.1058 mL
50 mM	0.0648 mL	0.3242 mL	0.6485 mL	3.2423 mL
100 mM	0.0324 mL	0.1621 mL	0.3242 mL	1.6212 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc