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Pepstatin Ammonium

Name: Pepstatin Ammonium
Brand: TargetMol
SKU: T12407
Rating: 4.5 (1 reviews)

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Catalog No. T12407

Alias Pepstatin A Ammonium

Pepstatin Ammonium is a specific inhibitor of aspartic proteaseproduced by actinomycetes(hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM , respectively). Pepstatin Ammonium also inhibits HIV protease.

Pepstatin Ammonium

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Catalog No. T12407Alias Pepstatin A Ammonium

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Product Introduction

Bioactivity

Description	Pepstatin Ammonium is a specific inhibitor of aspartic proteaseproduced by actinomycetes(hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM , respectively). Pepstatin Ammonium also inhibits HIV protease.
Targets&IC50	Casein-proctase:290 nM , Hemoglobin-acid protease:260 nM , Hemoglobin-proctase:6.2 nM , Hemoglobin-pepsin:4.5 nM , Casein-pepsin:150 nM , Casein-acid protease:520 nM
In vitro	Pepstatin inhibits the recombinant HIV protease with an IC50 of 250 μM.
In vivo	Pepstatin suppresses stomach ulceration of the pylorus in ligated Shay rats[1].
Synonyms	Pepstatin A Ammonium

Chemical Properties

Molecular Weight	702.92
Formula	C₃₄H₆₆N₆O₉
Smiles	CC(C)C[C@H](NC([C@@H](NC([C@@H](NC(CC(C)C)=O)C(C)C)=O)C(C)C)=O)[C@@H](O)CC(N[C@@H](C)C(N[C@@H](CC(C)C)[C@@H](O)CC(O)=O)=O)=O.N
Relative Density.	no data available
Sequence	isovaleryl-Val-Val-Sta-Ala-Sta-OH
Sequence Short	VVXAX

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 41.67 mg/mL (59.28 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (2.85 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4226 mL	7.1132 mL	14.2264 mL	71.1318 mL
5 mM	0.2845 mL	1.4226 mL	2.8453 mL	14.2264 mL
10 mM	0.1423 mL	0.7113 mL	1.4226 mL	7.1132 mL
20 mM	0.0711 mL	0.3557 mL	0.7113 mL	3.5566 mL
50 mM	0.0285 mL	0.1423 mL	0.2845 mL	1.4226 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc