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TCN 213
🥰Excellent
Catalog No. T8450Cas No. 556803-08-8
Alias TCN213
TCN 213 is an antagonist of NMDA receptor that has a selective for NR1/NR2A over NR1/NR2B
TCN 213
🥰Excellent
Purity: 99.68%
Catalog No. T8450Alias TCN213Cas No. 556803-08-8
TCN 213 is an antagonist of NMDA receptor that has a selective for NR1/NR2A over NR1/NR2B
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $41 | In Stock | |
| 25 mg | $83 | In Stock | |
| 50 mg | $138 | In Stock | |
| 100 mg | $226 | In Stock | |
| 200 mg | $326 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock |
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Purity:99.68%
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Product Introduction
Bioactivity
Chemical Properties
| Description | TCN 213 is an antagonist of NMDA receptor that has a selective for NR1/NR2A over NR1/NR2B |
| Targets&IC50 | GluN1/GluN2A NMDAR:0.55-40 μM (IC50) |
| In vitro | TCN 213 antagonism of GluN1/GluN2A NMDA receptors was dependent on glycine but independent of glutamate concentrations in external recording solutions.?Antagonism by TCN 213 was surmountable and gave a Schild plot with unity slope.?TCN 213 block of GluN1/GluN2B NMDA receptor-mediated currents was negligible.?In cortical neurones, at a early developmental stage predominantly expressing GluN2B-containing NMDA receptors, TCN 213 failed to antagonize NMDA receptor-mediated currents or to prevent GluN2B-dependent, NMDA-induced excitoxicity.?In older cultures (DIV 14) or in neurones transfected with GluN2A subunits, TCN 213 antagonized NMDA-evoked currents.?Block by TCN 213 of NMDA currents inversely correlated with block by ifenprodil, a selective GluN2B antagonist. |
| Synonyms | TCN213 |
| Molecular Weight | 376.54 |
| Formula | C18H24N4OS2 |
| Cas No. | 556803-08-8 |
| Smiles | O=C(CSc1nnc(NCc2ccccc2)s1)NCC1CCCCC1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (79.67 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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