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ICI 63197
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Catalog No. T22851Cas No. 27277-00-5
Alias 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one
ICI 63197 (2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one) is a PDE4 inhibitor.
ICI 63197
Copy Product Info🥰Excellent
Purity: 99.70%
Catalog No. T22851Alias 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-oneCas No. 27277-00-5
ICI 63197 (2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one) is a PDE4 inhibitor.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $35 | In Stock | In Stock | |
| 50 mg | $56 | In Stock | In Stock | |
| 100 mg | $77 | In Stock | In Stock | |
| 500 mg | $168 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.70%
Appearance:Solid
Color:White
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Product Introduction
ICI 63197 AI Summary
ICI 63197 shows bioactivity as an inhibitor in various assays related to different enzymes and pathways, including HSD17B4, JMJD2E, Cruzain, Cytochrome P450 2C19, ALDH1A1, Anthrax Lethal Toxin Internalization, HPGD, Cytochrome P450 2D6, Cytochrome P450 2C9, Lipid Storage Modulators, GCN5L2, Mammalian Selenoprotein Thioredoxin Reductase 1, and Arylsulfatase A. Additionally, it exhibits antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity of Caco-2 and VERO-6 cells, with inhibition rates of 6.71% and 1.48%, respectively, at a concentration of 10 µM after 48 hours. Furthermore, ICI 63197 inhibits the SARS-CoV-2 3CL-Pro protease by approximately 18.85% at a concentration of 20 µM. The compound also demonstrates inhibitory activity on the human HDAC6 enzyme, with inhibition percentages of -49.14% and -4.69% in enzymatic assays using commercial and custom peptide substrates, respectively, indicating its potential as an HDAC6 inhibitor..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | ICI 63197 (2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one) is a PDE4 inhibitor. |
| Targets&IC50 | PDE3:9 μM (Ki), PDE1:487 μM (Ki), PDE4:10 μM (Ki), PDE2:>1000 μM (Ki) |
| Synonyms | 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one |
| Molecular Weight | 207.23 |
| Formula | C9H13N5O |
| Cas No. | 27277-00-5 |
| Smiles | CCCn1c2nc(N)nn2cc(C)c1=O |
| Relative Density. | 1.44 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol: < 20 mg/mL, Sonication is recommended. DMSO: < 20 mg/mL, Sonication is recommended. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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