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Nosiheptide

Name: Nosiheptide
Brand: TargetMol
SKU: T16340
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16340Cas No. 56377-79-8

Alias RP 9671, Multhiomycin

Nosiheptide (Multhiomycin), a thiopeptide antibiotic produced by *Streptomyces actuosus*, is a potent feed additive that promotes animal growth by inhibiting bacterial protein synthesis. It is characterized by an indole side ring system and regiospecific hydroxyl groups on its macrocyclic core.

Nosiheptide

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Purity: 95.37%

Catalog No. T16340Alias RP 9671, MulthiomycinCas No. 56377-79-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	-	In Stock
5 mg	$81	-	In Stock
10 mg	$147	-	In Stock
25 mg	$297	-	In Stock
50 mg	$476	-	In Stock
100 mg	$763	-	In Stock
200 mg	$987	-	In Stock
1 mL x 10 mM (in DMSO)	$198	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:95.37%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Nosiheptide (Multhiomycin), a thiopeptide antibiotic produced by Streptomyces actuosus, is a potent feed additive that promotes animal growth by inhibiting bacterial protein synthesis. It is characterized by an indole side ring system and regiospecific hydroxyl groups on its macrocyclic core.
In vitro	Nosiheptide demonstrates non-toxic behavior towards mammalian cells at concentrations greater than 100 times the minimum inhibitory concentration (MIC) and retains its effectiveness against Staphylococcus aureus in the presence of 20% human serum. It is particularly potent against Enterococcus spp., the hypervirulent BI strain of Clostridium difficile, and displays remarkable activity against all tested strains of Staphylococcus aureus, including those resistant to multiple drugs (MIC values ≤ 0.25 mg/L). Additionally, Nosiheptide exhibits a significantly extended post-antibiotic effect against both healthcare- and community-associated Staphylococcus aureus when compared to vancomycin. Through time-kill studies, Nosiheptide has been found to quickly eliminate Staphylococcus aureus in a concentration- and time-dependent manner, achieving a near 2-log reduction at 6 hours with a concentration 10 times the MIC [1].
In vivo	Nosiheptide (20 mg/kg; intraperitoneal injection; administered at 1 and 8 hours post-infection; female CD1 mice) significantly protects against mortality, with all 10 treated mice surviving by day 3, compared to 6 out of 10 control mice dying on day 1[1].
Synonyms	RP 9671, Multhiomycin

Chemical Properties

Molecular Weight	1222.36
Formula	C₅₁H₄₃N₁₃O₁₂S₆
Cas No.	56377-79-8
Smiles	C\C=C1\NC(=O)C(NC(=O)c2csc(n2)-c2cc(O)c(nc2-c2csc(n2)C2CSC(=O)c3[nH]c4cccc(COC(=O)C(O)CC(NC(=O)c5csc1n5)c1nc(cs1)C(=O)N2)c4c3C)-c1nc(cs1)C(=O)NC(=C)C(N)=O)C(C)O
Relative Density.	1.534 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature,store under nitrogen | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (102.26 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8181 mL	4.0904 mL	8.1809 mL	40.9045 mL
5 mM	0.1636 mL	0.8181 mL	1.6362 mL	8.1809 mL
10 mM	0.0818 mL	0.4090 mL	0.8181 mL	4.0904 mL
20 mM	0.0409 mL	0.2045 mL	0.4090 mL	2.0452 mL
50 mM	0.0164 mL	0.0818 mL	0.1636 mL	0.8181 mL
100 mM	0.0082 mL	0.0409 mL	0.0818 mL	0.4090 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc