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Anti-ADAM17 Antibody (7B343)
😃Good
Catalog No. TMAH-00027
Alias TNF-alpha-converting enzyme, TNF-alpha convertase, Snake venom-like protease, EC 3.4.24.86, Disintegrin and metalloproteinase domain-containing protein 17, CSVP TACE, CD antigen CD156b, ADAM 17
Anti-ADAM17 Antibody (7B343) is an antibody targeting ADAM17. Anti-ADAM17 Antibody (7B343) can be used in ELISA, IF.
Anti-ADAM17 Antibody (7B343)
Anti-ADAM17 Antibody (7B343)
😃Good
Catalog No. TMAH-00027Alias TNF-alpha-converting enzyme, TNF-alpha convertase, Snake venom-like protease, EC 3.4.24.86, Disintegrin and metalloproteinase domain-containing protein 17, CSVP TACE, CD antigen CD156b, ADAM 17
Anti-ADAM17 Antibody (7B343) is an antibody targeting ADAM17. Anti-ADAM17 Antibody (7B343) can be used in ELISA, IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $209 | 7-10 days | |
| 100 μL | $348 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Rabbit Monoclonal Application: ELISA, IF Reactivity: Human |
| Alias | TNF-alpha-converting enzyme, TNF-alpha convertase, Snake venom-like protease, EC 3.4.24.86, Disintegrin and metalloproteinase domain-containing protein 17, CSVP TACE, CD antigen CD156b, ADAM 17 |
| Ig Type | Rabbit IgG |
| Clone | 7B343 |
| Reactivity | Human |
| Verified Activity | Immunofluorescence staining of Hela Cells with TMAH-00027 at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L). |
| Application | ELISA, IF |
| Recommended Dose | IF:1:20-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Membrane; Single-pass type I membrane protein. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2. Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain. Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3. Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human ADAM17 |
| Antigen Species | Human |
| Gene ID | 6868 |
| Uniprot ID | |
| Biology Area | Neuroscience, Cancer, Cell biology, Metabolism, Signal transduction, Stem cells |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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