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Anti-ADAM17 Antibody (7B343)
🥰Excellent
Catalog No. TMAH-00027
Alias TNF-alpha-converting enzyme, TNF-alpha convertase, Snake venom-like protease, EC 3.4.24.86, Disintegrin and metalloproteinase domain-containing protein 17, CSVP TACE, CD antigen CD156b, ADAM 17
Anti-ADAM17 Antibody (7B343) is an antibody targeting ADAM17. Anti-ADAM17 Antibody (7B343) can be used in ELISA, IF.
Anti-ADAM17 Antibody (7B343)
Anti-ADAM17 Antibody (7B343)
🥰Excellent
Catalog No. TMAH-00027Alias TNF-alpha-converting enzyme, TNF-alpha convertase, Snake venom-like protease, EC 3.4.24.86, Disintegrin and metalloproteinase domain-containing protein 17, CSVP TACE, CD antigen CD156b, ADAM 17
Anti-ADAM17 Antibody (7B343) is an antibody targeting ADAM17. Anti-ADAM17 Antibody (7B343) can be used in ELISA, IF.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-ADAM17 Antibody (7B343) is an antibody targeting ADAM17. Anti-ADAM17 Antibody (7B343) can be used in ELISA, IF. |
| Alias | TNF-alpha-converting enzyme, TNF-alpha convertase, Snake venom-like protease, EC 3.4.24.86, Disintegrin and metalloproteinase domain-containing protein 17, CSVP TACE, CD antigen CD156b, ADAM 17 |
| Ig Type | Rabbit IgG |
| Clone | 7B343 |
| Reactivity | Human |
| Verified Activity | Immunofluorescence staining of Hela Cells with TMAH-00027 at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L). |
| Application | ELISA, IF |
| Recommended Dose | IF:1:20-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Membrane; Single-pass type I membrane protein. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellu... |
| Conjucates | Unconjugated |
| Immunogen | A synthesized peptide derived from human ADAM17 |
| Antigen Species | Human |
| Gene ID | 6868 |
| Uniprot ID | |
| Biology Area | Neuroscience, Cancer, Cell biology, Metabolism, Signal transduction, Stem cells |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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