S-Allylmercaptocysteine HCl is an organosulfur compound isolated from aged garlic with anti-inflammatory, antioxidant, anticancer, and antitumor activities.S-Allylmercaptocysteine HCl inhibits inflammation in COPD and targets Nrf2 in osteoarthritis therapy through the NOX4/NF-kappaB pathway. Targeting Nrf2.

S-Allylmercaptocysteine HCl induced apoptosis in SW620, SW480, and Caco-2 cells, and activated caspase 3 and cleaved PARP1 were found in cells treated with S-Allylmercaptocysteine HCl, whereas they were not found in untreated control cells activated PARP1 and caspase 3. [1]
S-Allylmercaptocysteine HCl attenuated cisplatin-induced nephrotoxicity by inhibiting apoptosis, oxidative stress and inflammation. [2]

Oral administration of 25 and 50 mg/kg S-Allylmercaptocysteine HCl ,significantly ameliorated the pathology of BLM-induced pulmonary fibrosis in mice, showing antifibrotic effects by increasing antioxidants such as heme oxygenase-1 (HO-1), glutathione (GSH) and superoxide dismutase (SOD), and decreasing hydroxyproline (HYP).
S-Allylmercaptocysteine HCl reduced inflammatory cell infiltration in bronchoalveolar lavage fluid (BALF) and decreased pro-inflammatory cytokine levels in BALF.[3]