Anti-UBE2N Antibody (4R885) is a Rabbit antibody targeting UBE2N. Anti-UBE2N Antibody (4R885) can be used in ICC/IF, IF, IHC-Fr, IHC-P, WB.

IgG

4R885

Human,Mouse,Rat

25 ug total protein per lane of various lysates (see on figure) probed with UBE2N monoclonal antibody, unconjugated (TMAB-13941) at 1: 1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r. T. for 60 min.

ICC/IF=1:50-200; IF=1:50-200; IHC-Fr=1:100-200; IHC-P=1:100-200; WB=1:500-2000

Monoclonal

A synthesized peptide: human UBE2N

Human

UBE2N

Ubiquitin-conjugating enzyme E2 N

The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD.