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Nepafenac

Name: Nepafenac
Brand: TargetMol
SKU: T1280
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1280Cas No. 78281-72-8

Alias AL 6515, AHR 9434

Nepafenac (AHR 9434) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of nepafenac is as a Cyclooxygenase Inhibitor. The chemical classification of nepafenac is Nonsteroidal Anti-inflammatory Compounds.

Nepafenac

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Purity: 99.43%

Catalog No. T1280Alias AL 6515, AHR 9434Cas No. 78281-72-8

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$35	In Stock	In Stock
50 mg	$58	In Stock	In Stock
100 mg	$98	In Stock	In Stock
500 mg	$238	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$40	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.43%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Nepafenac (AHR 9434) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of nepafenac is as a Cyclooxygenase Inhibitor. The chemical classification of nepafenac is Nonsteroidal Anti-inflammatory Compounds.
Targets&IC50	COX-1:64.3 μM (IC50)
Synonyms	AL 6515, AHR 9434

Chemical Properties

Molecular Weight	254.28
Formula	C₁₅H₁₄N₂O₂
Cas No.	78281-72-8
Smiles	NC(=O)Cc1cccc(C(=O)c2ccccc2)c1N
Relative Density.	1.249 g/cm3
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 60 mg/mL (235.96 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9327 mL	19.6634 mL	39.3267 mL	196.6336 mL
5 mM	0.7865 mL	3.9327 mL	7.8653 mL	39.3267 mL
10 mM	0.3933 mL	1.9663 mL	3.9327 mL	19.6634 mL
20 mM	0.1966 mL	0.9832 mL	1.9663 mL	9.8317 mL
50 mM	0.0787 mL	0.3933 mL	0.7865 mL	3.9327 mL
100 mM	0.0393 mL	0.1966 mL	0.3933 mL	1.9663 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc