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ST2/IL-1 RL1 Protein, Human, Recombinant

Catalog No. TMPY-00850
Synonyms: ST2, IL1RL1, ST2L, IL33R, T1, DER4, ST2V, IL‑1 R4, interleukin 1 receptor-like 1, FIT-1

ST2/IL-1 RL1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 35.6 kDa and the accession number is Q01638-2.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
ST2/IL-1 RL1 Protein, Human, Recombinant
Pack Size Availability Price/USD Quantity
100 μg In stock $ 386.00
200 μg 5 days $ 660.00
500 μg 5 days $ 1,340.00
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Biological Description
Technical Params
Product Properties
References and Literature
Biological Information Testing in progress
Description ST2/IL-1 RL1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 35.6 kDa and the accession number is Q01638-2.
Species Human
Expression System HEK293 Cells
Tag Tag Free
Accession Number Q01638-2
Synonyms ST2, IL1RL1, ST2L, IL33R, T1, DER4, ST2V, IL‑1 R4, interleukin 1 receptor-like 1, FIT-1
Construction The secreted isoform of Human IL1RL1 (NP_003847.2) (Met 1-Phe 328) with five amino acids (DDDDK) at the C-terminus was expressed and purified.
Protein Purity > 95 % as determined by SDS-PAGE

Molecular Weight 35.6 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing 50 mM Tris, 100 mM NaCl, pH 8.0.Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage proinflammatory function. IL33 is a specific ligand of ST2L and induces the production of Th2 cytokines.

References and Literature

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Keywords

ST2/IL-1 RL1 Protein, Human, Recombinant ST2 IL1RL1 FIT 1 ST-2 DER-4 T-1 ST2L IL33R T1 FIT1 DER 4 T 1 DER4 ST2V IL‑1 R4 interleukin 1 receptor-like 1 ST 2 FIT-1 recombinant recombinant-proteins proteins protein

 

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