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Decoyinine

Name: Decoyinine
Brand: TargetMol
SKU: T15091
Price: 65 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15091Cas No. 2004-04-8

Alias Decynylene, Angustmycin A

Decoyinine (Decynylene), a selective inhibitor of GMP synthase, is a novel potential microbial insecticide, a secondary metabolite produced by Streptomyces hygroscopicus.Decoyinine induces resistance in rice to the small brown ladybug Laodelphax striatellus.

Decoyinine

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Purity: 99.98%

Catalog No. T15091Alias Decynylene, Angustmycin ACas No. 2004-04-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$65	In Stock	In Stock
5 mg	$279	In Stock	In Stock
10 mg	$492	-	In Stock
25 mg	$787	-	In Stock
1 mL x 10 mM (in DMSO)	$239	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.98%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Decoyinine (Decynylene), a selective inhibitor of GMP synthase, is a novel potential microbial insecticide, a secondary metabolite produced by Streptomyces hygroscopicus.Decoyinine induces resistance in rice to the small brown ladybug Laodelphax striatellus.
In vitro	Decoyinine exerts a stimulatory effect on oaamylase synthesis only in the strain in which the catabolite repression component of a-amylase regulation has been rendered inoperable by the gra-10 mutation. Decoyinine is an analog of adenosine which causes a decrease in intracellular GTP levels by inhibition of GMP synthetase. The apparent stimnulation of a-amylase activity in WLN-11 by Decoyinine is not an artifactual effect exerted at the level of enzyme activity itself. At the concentration used in the experiments (1.07 mM), Decoyinine has no effect in vitro on B. subtilis WLN-11 oaamylase activity. At the same concentration, GMP exerts a slight inhibitory effect on aamylase activity.[2]
In vivo	Decoyinine (Angustmycin A) treatment hinders tumor growth in xenograft mouse model. Like GMPS activity, the effect of Decoyinine does not appear to be subtype specific as it impairs growth of xenografts from cells harboring NRASQ61R (SK-Mel-103) or BRAFV600E (SK-Mel-28) mutations.[1]
Synonyms	Decynylene, Angustmycin A

Chemical Properties

Molecular Weight	279.25
Formula	C₁₁H₁₃N₅O₄
Cas No.	2004-04-8
Smiles	Nc1ncnc2n(cnc12)[C@]1(CO)OC(=CO)[C@@H](O)[C@H]1O
Relative Density.	1.87 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (161.15 mM), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5810 mL	17.9051 mL	35.8102 mL	179.0510 mL
5 mM	0.7162 mL	3.5810 mL	7.1620 mL	35.8102 mL
10 mM	0.3581 mL	1.7905 mL	3.5810 mL	17.9051 mL
20 mM	0.1791 mL	0.8953 mL	1.7905 mL	8.9526 mL
50 mM	0.0716 mL	0.3581 mL	0.7162 mL	3.5810 mL
100 mM	0.0358 mL	0.1791 mL	0.3581 mL	1.7905 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc