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Anti-gp130/IL6ST Antibody-PE (9A213)
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Catalog No. TMAY-01389P
Alias interleukin 6 signal transducer, IL-6RB, GP130, CDW130, CD130
Anti-gp130/IL6ST Antibody-PE (9A213) is a PE-conjugated Mouse antibody targeting gp130/IL6ST. Anti-gp130/IL6ST Antibody-PE (9A213) can be used in FCM.
Anti-gp130/IL6ST Antibody-PE (9A213)
Anti-gp130/IL6ST Antibody-PE (9A213)
😃Good
Catalog No. TMAY-01389PAlias interleukin 6 signal transducer, IL-6RB, GP130, CDW130, CD130
Anti-gp130/IL6ST Antibody-PE (9A213) is a PE-conjugated Mouse antibody targeting gp130/IL6ST. Anti-gp130/IL6ST Antibody-PE (9A213) can be used in FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 T | $104 | 7-10 days | |
| 100 T | $328 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: FCM Reactivity: Human |
| Alias | interleukin 6 signal transducer, IL-6RB, GP130, CDW130, CD130 |
| Ig Type | Mouse IgG2a |
| Clone | 9A213 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human IL6RB(CD130) expression on human whole blood Lymphocytes. Cells were stained with PE-conjugated anti-Human IL6RB(CD130). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable Lymphocytes. |
| Application | FCM |
| Recommended Dose | 10 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL6ST/gp130/CD130 (rh IL6ST/gp130/CD130; NP_002175.2Met1-Ile618) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Research Background | Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta, or CD130) is a transmembrane protein that is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD130/gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD130/gp130 plays a critical role in regulating myocyte apoptosis. Alternatively, spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1, and BSF3 can utilize gp130 for initiating signal transmission. CD130/gp130 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD130/gp130 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events. |
| Conjucates | PE |
| Others Formats | Unconjugated |
| Antibody Types Available | 2 |
| Immunogen | Recombinant Protein: Human IL6ST/gp130/CD130 Protein |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Transport | Shipping with blue ice. |
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