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Anti-TRK fused gene Antibody (4L658)
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Catalog No. TMAC-04130
Alias TRKT3 oncogene, TRKT3, TRK-fused gene protein, TRK fused gene protein, TRK fused gene, TRK fused, TFG_HUMAN, TFG, TF6, SPG57, Protein TFG, OTTHUMP00000214048, OTTHUMP00000214047, OTTHUMP00000214046, OTTHUMP00000214045, HMSNP, FLJ36137
Anti-TRK fused gene Antibody (4L658) is a Rabbit antibody targeting TRK fused gene. Anti-TRK fused gene Antibody (4L658) can be used in WB,ICC/IF,IHC,IP.
Anti-TRK fused gene Antibody (4L658)
Anti-TRK fused gene Antibody (4L658)
😃Good
Catalog No. TMAC-04130Alias TRKT3 oncogene, TRKT3, TRK-fused gene protein, TRK fused gene protein, TRK fused gene, TRK fused, TFG_HUMAN, TFG, TF6, SPG57, Protein TFG, OTTHUMP00000214048, OTTHUMP00000214047, OTTHUMP00000214046, OTTHUMP00000214045, HMSNP, FLJ36137
Anti-TRK fused gene Antibody (4L658) is a Rabbit antibody targeting TRK fused gene. Anti-TRK fused gene Antibody (4L658) can be used in WB,ICC/IF,IHC,IP.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $297 | 7-10 days | |
| 100 μL | $496 | 7-10 days |
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| Description | Anti-TRK fused gene Antibody (4L658) is a Rabbit antibody targeting TRK fused gene. Anti-TRK fused gene Antibody (4L658) can be used in WB,ICC/IF,IHC,IP. |
| Synonyms | TRKT3 oncogene, TRKT3, TRK-fused gene protein, TRK fused gene protein, TRK fused gene, TRK fused, TFG_HUMAN, TFG, TF6, SPG57, Protein TFG, OTTHUMP00000214048, OTTHUMP00000214047, OTTHUMP00000214046, OTTHUMP00000214045, HMSNP, FLJ36137 |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Western blot analysis of TRK fused gene on different lysates using anti-TRK fused gene antibody at 1/5,000 dilution. Positive control: Lane 1: 293T, Lane 2: Hela. 2. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-TRK fused gene antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-TRK fused gene antibody. Counter stained with hematoxylin. 4. Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-TRK fused gene antibody. Counter stained with hematoxylin. 5. Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using anti-TRK fused gene antibody. Counter stained with hematoxylin. 6. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-TRK fused gene antibody. Counter stained with hematoxylin. 7. ICC staining TRK fused gene in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 8. ICC staining TRK fused gene in SKOV-3 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 9. ICC staining TRK fused gene in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. |
| Application | |
| Recommended Dose | WB: 1:1000-2000; IHC: 1:50-200; ICC/IF: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | Oncogenic rearrangements of the NTRK1 gene, which encodes the Trk A protein, are frequently detected in thyroid carcinomas. Such rearrangements fuse the NTRK1 tyrosine kinase domain to 5'-end sequences of different genes. TRK-T3 contains 1,412 nucleotides of NTRK1 preceded by 598 nucleotides belonging to TFG (TRK-fused gene), a ubiquitously expressed gene located on chromosome 3. The TRK-T3 protein within the TFG region contains a coiled-coil motif that gives the oncoprotein the capability to form complexes. The cytoplasmic TRK-T3 protein binds to and phosphorylates the Shc and SNT1/FRS2 adaptor proteins, both of which are involved in coupling the receptor tyrosine kinase to the mitogen-activated protein kinase pathway by recruiting Grb2/SOS. SHP-1 also interacts with and down-regulates TRK-T3. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 55 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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