Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PHD2-IN-1, a potent and orally active HIF prolyl hydroxylase 2 (PHD2) inhibitor, exhibits an IC50 of 22.53 nM and is applicable in anemia research [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 8-10 weeks | $ 1,520.00 | |
50 mg | 8-10 weeks | $ 1,980.00 | |
100 mg | 8-10 weeks | $ 2,500.00 |
Description | PHD2-IN-1, a potent and orally active HIF prolyl hydroxylase 2 (PHD2) inhibitor, exhibits an IC50 of 22.53 nM and is applicable in anemia research [1]. |
In vitro | PHD2-IN-1 (Compound 22), at concentrations ranging from 0-50 µM and applied over a period of 12 hours, stabilizes HIF-α and enhances the expression of the erythropoietin (EPO) gene. |
In vivo | PHD2-IN-1 (Compound 22) administered orally at doses of 10, 20, and 50 mg/kg once daily for three consecutive days stimulated erythropoiesis and increased reticulocyte counts in a dose-dependent manner in C57BL/6 mice [1]. When injected intraperitoneally at doses of 50, 100, and 200 mg/kg in ICR mice, PHD2-IN-1 exhibited no significant toxic responses after once-daily administrations for three days [1]. Additionally, pharmacokinetic analysis indicated that PHD2-IN-1 has a half-life (T 1/2) of 2.29 hours when administered orally and 3.72 hours intravenously in rats, and 1.17 hours orally and 0.33 hours intravenously in mice. The oral bioavailability (F%) of PHD2-IN-1 was reported as 33.9% in rats and 35.3% in mice [1]. The pharmacokinetic parameters for PHD2-IN-1 in SD rats and C57BL/6 mice, including Tmax, Cmax, AUC0-t, AUC0-∞, T 1/2, clearance (CL), volume of distribution (Vz), mean residence time (MRT) and bioavailability (F%) across different administration routes and dosages, are summarized in the provided table [1]. |
Molecular Weight | 446.88 |
Formula | C21H23ClN4O5 |
CAS No. | 2768219-28-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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PHD2-IN-1 2768219-28-7 Chromatin/Epigenetic Metabolism HIF/HIF Prolyl-Hydroxylase inhibitor inhibit