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Anti-IGFBP-2 Antibody (1S652)
🥰Excellent
Catalog No. TMAY-03888
Anti-IGFBP-2 Antibody (1S652) is a Mouse antibody targeting IGFBP-2. Anti-IGFBP-2 Antibody (1S652) can be used in IHC-P.
Anti-IGFBP-2 Antibody (1S652)
Anti-IGFBP-2 Antibody (1S652)
🥰Excellent
Catalog No. TMAY-03888
Anti-IGFBP-2 Antibody (1S652) is a Mouse antibody targeting IGFBP-2. Anti-IGFBP-2 Antibody (1S652) can be used in IHC-P.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-IGFBP-2 Antibody (1S652) is a Mouse antibody targeting IGFBP-2. Anti-IGFBP-2 Antibody (1S652) can be used in IHC-P. |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 1S652 |
| Reactivity | Rhesus |
| Verified Activity | 1. Immunochemical staining of Rhesus IGFBP2 in Rhesus liver with mouse monoclonal antibody (1:30, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of Rhesus IGFBP2 in Rhesus kidney with mouse monoclonal antibody (1:30, formalin-fixed paraffin embedded sections). 3. Immunochemical staining of Rhesus IGFBP2 in Rhesus heart with mouse monoclonal antibody (1:30, formalin-fixed paraffin embedded sections). |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:20-1:80 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rhesus IGFBP-2 / IGFBP2 ( TMPY-02969; XP_001087071.1; Met1-Gln324). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | IGFBP-2, also known as IGFBP2, is an insulin-like growth factor-binding protein (IGFBP). IGFBPs prolong the half-life of the IGFs, control bioavailability, activity, and distribution of insulin-like growth factor (IGF) through high-affinity IGFBP/IGF complexes. Six high-affinity IGF-binding proteins (IGFBP-1 to -6) have been identified. The six IGFBPs are structurally related but encoded by distinct genes. IGFBPs have a high affinity for IGFs. Some members of the IGFBP family have been consistently shown to inhibit IGF actions by preventing them from gaining access to the IGF receptors, while others potentiate IGF actions by facilitating the ligand-receptor interaction. IGFBP-2 is overexpressed in many malignancies and is often correlated with an increasingly malignant status of the tumor, pointing to the potential involvement of IGFBP-2 in tumorigenesis. It contains 1 IGFBP N-terminal domain and 1 thyroglobulin type-1 domain. It inhibits IGF-mediated growth and developmental rates. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Rhesus IGFBP-2 / IGFBP2 Protein (TMPY-02969) |
| Antigen Species | Rhesus |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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