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VER-49009

Name: VER-49009
Brand: TargetMol
SKU: T3454
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3454Cas No. 558640-51-0

Alias CCT 129397

VER-49009 (CCT 129397) is a potent Hsp90 inhibitor(IC50 of 25 nM and Kd of 78 nM).

VER-49009

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Purity: 99.99%

Catalog No. T3454Alias CCT 129397Cas No. 558640-51-0

VER-49009 (CCT 129397) is a potent Hsp90 inhibitor(IC50 of 25 nM and Kd of 78 nM).

Pack Size	Price	Availability
2 mg	$38	In Stock
5 mg	$58	In Stock
10 mg	$93	In Stock
25 mg	$167	In Stock
50 mg	$273	In Stock
100 mg	$373	In Stock
200 mg	$527	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock

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Purity:99.99%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	VER-49009 (CCT 129397) is a potent Hsp90 inhibitor(IC50 of 25 nM and Kd of 78 nM).
Targets&IC50	HSP90:78 nM(kd), HSP90:25 nM
In vitro	VER-49009 inhibited the proliferation of hepatic stellate cell line CFSC cells, and both of them induced G2 phase arrest in CFSC cells[1].
In vivo	Treatmented with VER-49009 results in clear depletion of ERBB2 at 3 and 8 h following the final dose, with client protein levels returning to normal by 24 h, in the athymic mice bearing well-established OVCAR3 human ovarian ascites tumors[2].
Kinase Assay	Fluorescence Polarization Assay: Binding of HSP90 inhibitors to human full-length recombinant HSP90β is determined by a competitive binding fluorescence polarization assay, using a fluorescent pyrazole resorcinol probe.
Cell Research	Antiproliferative effects are measured using the sulforhodamine B assay. HUVEC sensitivity is determined by an alkaline phosphatase method. (Only for Reference)
Synonyms	CCT 129397

Chemical Properties

Molecular Weight	387.82
Formula	C₁₉H₁₈ClN₃O₄
Cas No.	558640-51-0
Smiles	CCNC(=O)c1n[nH]c(c1-c1ccc(OC)cc1)-c1cc(Cl)c(O)cc1O
Relative Density.	1.379 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (257.85 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5785 mL	12.8926 mL	25.7852 mL	128.9258 mL
5 mM	0.5157 mL	2.5785 mL	5.1570 mL	25.7852 mL
10 mM	0.2579 mL	1.2893 mL	2.5785 mL	12.8926 mL
20 mM	0.1289 mL	0.6446 mL	1.2893 mL	6.4463 mL
50 mM	0.0516 mL	0.2579 mL	0.5157 mL	2.5785 mL
100 mM	0.0258 mL	0.1289 mL	0.2579 mL	1.2893 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc