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Mestranol

Name: Mestranol
Brand: TargetMol
SKU: T1579
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1579Cas No. 72-33-3

Alias Norquen, Menophase, Devocin

Mestranol (Devocin), a semisynthetic estrogen, is used as an estrogen receptor agonist and must be demethylated to be biologically active.

Mestranol

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Purity: 99.16%

Catalog No. T1579Alias Norquen, Menophase, DevocinCas No. 72-33-3

Mestranol (Devocin), a semisynthetic estrogen, is used as an estrogen receptor agonist and must be demethylated to be biologically active.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$36	In Stock	In Stock
100 mg	$52	In Stock	In Stock
200 mg	$72	In Stock	In Stock
500 mg	$116	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$58	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.16%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Mestranol AI Summary

Mestranol exhibits a high oral antifertility potency in rats, exceeding that of ethynylestradiol at doses greater than 2.0 mg/kg/day, and demonstrates lower oral estrogenic potency than ethynylestradiol at 0.3 mg/kg/day. It shows oral estrogenic activity in uterotropic assays in rats at doses ranging from 100 to 10,000 ng, causing a decrease in weight by 65.3 mg. Mestranol is involved in diverse biological activities, including modulation of Lamin A splicing, mitochondrial fusion, and inhibition of ROR gamma, GCN5L2, and human tyrosyl-DNA phosphodiesterase 1 among others. It also inhibits chronic active B-cell receptor signaling, malarial parasite plastid function, and HP1-beta chromodomain interactions, and corrects the CFTR Delta508 mutation and blocks Ebola virus entry. In radioligand binding assays, Mestranol shows moderate potency in inhibiting the Norepinephrine Transporter and higher affinity for the Estrogen ERalpha receptor, while displaying weaker interactions with other receptors such as Cannabinoid CB1 and Progesterone receptors. It also exhibits inhibitory effects on the Serotonin transporter and moderate potency against the Sodium Channel, Site 2. Moreover, this compound has shown potent inhibition of the human CYP3A4 enzyme system. In anti-viral assays, Mestranol demonstrates inhibition of SARS-CoV-2 induced cytotoxicity in Vero E6 and Caco-2 cells, and inhibition of SARS-CoV-2 3CL-Pro protease activity. It also exhibits antifungal activity against Candida albicans and some antibacterial activities against various bacterial strains including Klebsiella pneumoniae and Pseudomonas aeruginosa. Additionally, it shows antiproliferative activity against human MCF7 cells with an IC50 value of 40.0 nM. In FDA HLAED assays, it shows varied liver enzyme activity, indicating potential effects on liver function. Mestranol also participates in numerous physiological processes as suggested by bioactivity in assays related to liver and kidney functions, electrolyte balance, and hematologic parameters. Overall, Mestranol presents a broad spectrum of bioactivities, making it a significant candidate for further biomedical research across multiple therapeutic areas..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Mestranol (Devocin), a semisynthetic estrogen, is used as an estrogen receptor agonist and must be demethylated to be biologically active.
In vitro	Mestranolol can act on estrogen receptor (ER) and is metabolized to hydroxylated products.
In vivo	Mestranolol can act on estrogen receptor (ER) and is metabolized to hydroxylated products.
Synonyms	Norquen, Menophase, Devocin

Chemical Properties

Molecular Weight	310.43
Formula	C₂₁H₂₆O₂
Cas No.	72-33-3
Smiles	COC1=CC2=C(C=C1)C1CCC3(C)C(CCC3(O)C#C)C1CC2
Relative Density.	1.0865 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 12 mg/mL (38.66 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 24 mg/mL (77.31 mM), Sonication is recommended.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	3.2213 mL	16.1067 mL	32.2134 mL	161.0669 mL
5 mM	0.6443 mL	3.2213 mL	6.4427 mL	32.2134 mL
10 mM	0.3221 mL	1.6107 mL	3.2213 mL	16.1067 mL
20 mM	0.1611 mL	0.8053 mL	1.6107 mL	8.0533 mL

Ethanol

	1mg	5mg	10mg	50mg
50 mM	0.0644 mL	0.3221 mL	0.6443 mL	3.2213 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc