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Anti-EGR2 Antibody (7J609)
😃Good
Catalog No. TMAH-00381
Alias Zinc finger protein Krox-20, KROX20, EGR-2, EGR2, Early growth response protein 2, E3 SUMO-protein transferase ERG2, E3 SUMO-protein ligase EGR2, AT591
Anti-EGR2 Antibody (7J609) is an antibody targeting EGR2. Anti-EGR2 Antibody (7J609) can be used in ELISA, WB, FC.
Anti-EGR2 Antibody (7J609)
Anti-EGR2 Antibody (7J609)
😃Good
Catalog No. TMAH-00381Alias Zinc finger protein Krox-20, KROX20, EGR-2, EGR2, Early growth response protein 2, E3 SUMO-protein transferase ERG2, E3 SUMO-protein ligase EGR2, AT591
Anti-EGR2 Antibody (7J609) is an antibody targeting EGR2. Anti-EGR2 Antibody (7J609) can be used in ELISA, WB, FC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $209 | 7-10 days | |
| 100 μL | $348 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Monoclonal Application: ELISA, WB, FC Reactivity: Human, Mouse |
| Alias | Zinc finger protein Krox-20, KROX20, EGR-2, EGR2, Early growth response protein 2, E3 SUMO-protein transferase ERG2, E3 SUMO-protein ligase EGR2, AT591 |
| Ig Type | Rabbit IgG |
| Clone | 7J609 |
| Reactivity | Human, Mouse |
| Verified Activity | 1. Western Blot -Positive WB detected in: SY5Y whole cell lysate,U251 whole cell lysate,MCF7 whole cell lysate,K562 whole cell lysate,Mouse Brain tissue lysate,Mouse Brain tissue lysate -All lanes: EGR2 antibody at 1:1000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 50 kDa -Observed band size: 50 kDa 2. Overlay Peak curve showing SH-SY5Y cells stained with TMAH-00381 (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1µg/1*10^6 cells) for 45min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4°C.Control antibody (green line) was rabbit IgG (1µg/1*10^6 cells) used under the same conditions. Acquisition of >10,000 events was performed. |
| Application | ELISA, WB, FC |
| Recommended Dose | WB:1:500-1:2000; FC:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Nucleus. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Sequence-specific DNA-binding transcription factor. Plays a role in hindbrain segmentation by regulating the expression of a subset of homeobox containing genes and in Schwann cell myelination by regulating the expression of genes involved in the formation and maintenance of myelin. Binds to two EGR2-consensus sites EGR2A (5'-CTGTAGGAG-3') and EGR2B (5'-ATGTAGGTG-3') in the HOXB3 enhancer and promotes HOXB3 transcriptional activation. Binds to specific DNA sites located in the promoter region of HOXA4, HOXB2 and ERBB2. Regulates hindbrain segmentation by controlling the expression of Hox genes, such as HOXA4, HOXB3 and HOXB2, and thereby specifying odd and even rhombomeres. Promotes the expression of HOXB3 in the rhombomere r5 in the hindbrain. Regulates myelination in the peripheral nervous system after birth, possibly by regulating the expression of myelin proteins, such as MPZ, and by promoting the differentiation of Schwann cells. Involved in the development of the jaw openener musculature, probably by playing a role in its innervation through trigeminal motor neurons. May play a role in adipogenesis, possibly by regulating the expression of CEBPB. E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 transcriptional activity. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human EGR2 |
| Antigen Species | Human |
| Gene ID | 1959 |
| Uniprot ID | |
| Biology Area | Epigenetics and Nuclear Signaling, Neuroscience |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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