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Anti-SLC7A5 Polyclonal Antibody
😃Good
Catalog No. TMAB-01730
Alias y+ system cationic amino acid transporter, Solute carrier family 7 member 5, SLC7A5, MPE16, L-type amino acid transporter 1 (hLAT1), LAT1, Large neutral amino acids transporter small subunit 1, Integral membrane protein E16 (E16), CD98LC, CD98 light chain, 4F2 light chain (4F2 LC;4F2LC)
Anti-SLC7A5 Polyclonal Antibody is a Rabbit antibody targeting SLC7A5. Anti-SLC7A5 Polyclonal Antibody can be used in WB.
Anti-SLC7A5 Polyclonal Antibody
Anti-SLC7A5 Polyclonal Antibody
😃Good
Catalog No. TMAB-01730Alias y+ system cationic amino acid transporter, Solute carrier family 7 member 5, SLC7A5, MPE16, L-type amino acid transporter 1 (hLAT1), LAT1, Large neutral amino acids transporter small subunit 1, Integral membrane protein E16 (E16), CD98LC, CD98 light chain, 4F2 light chain (4F2 LC;4F2LC)
Anti-SLC7A5 Polyclonal Antibody is a Rabbit antibody targeting SLC7A5. Anti-SLC7A5 Polyclonal Antibody can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $222 | 7-10 days | |
| 100 μL | $374 | 7-10 days | |
| 200 μL | $529 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-SLC7A5 Polyclonal Antibody is a Rabbit antibody targeting SLC7A5. Anti-SLC7A5 Polyclonal Antibody can be used in WB. |
| Alias | y+ system cationic amino acid transporter, Solute carrier family 7 member 5, SLC7A5, MPE16, L-type amino acid transporter 1 (hLAT1), LAT1, Large neutral amino acids transporter small subunit 1, Integral membrane protein E16 (E16), CD98LC, CD98 light chain, 4F2 light chain (4F2 LC;4F2LC) |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Rat) |
| Verified Activity | Sample: Brain (Rat) Lysate at 40 μg Primary: Anti-SLC7A5 (TMAB-01730) at 1/300 dilution Secondary: HRP conjugated Goat-Anti-rabbit IgG (secondary antibody) at 1/5000 dilution Predicted band size: 55 kDa Observed band size: 55 kDa |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm, cytosol. Apical cell membrane. Located to the plasma membrane by SLC3A2/4F2hc. Localized to the apical membrane of placental syncytiophoblastic cells. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Research Background | L-type amino acid transporter 1 (LAT1) is a multipass-membrane protein responsible for sodium-independent, high-affinity transport of large neutral amino acids. LAT1 functions as a disulfide-linked heterodimer with the amino acid transport protein CD98. LAT1 is expressed predominantly in adult lung and liver but is also expressed in brain, thymus, retina, testis, placenta, bone marrow and fetal liver. In the retina, LAT1 localizes to the blood-retinal-barrier (BRB) and mediates L-leucine transport from the blood to the retina. The devastating effects on the brain caused by phenylketonuria are due to the increased levels of LAT1 on the blood-brain-barrier in response to high concentrations of phenylalanine in the blood. LAT1 accepts the amino-acid related anticancer agent melphalan and plays a significant role in cell proliferation, differentiation, and invasion in esophageal squamous cell carcinoma. |
| Immunogen | KLH conjugated synthetic peptide: human SLC7A5 |
| Antigen Species | Human |
| Gene ID | |
| Uniprot ID |
| Molecular Weight | Theoretical: 55 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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