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MS159
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Catalog No. T77967Cas No. 3031353-59-7
MS159 is a potent PROTAC degrader targeting the nuclear receptor binding SET structural domain protein 2 (NSD2), which inhibits tumor cell growth. This compound serves as a valuable chemical tool for investigating NSD2's function in health and disease [1].
MS159
😃Good
Catalog No. T77967Cas No. 3031353-59-7
MS159 is a potent PROTAC degrader targeting the nuclear receptor binding SET structural domain protein 2 (NSD2), which inhibits tumor cell growth. This compound serves as a valuable chemical tool for investigating NSD2's function in health and disease [1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | MS159 is a potent PROTAC degrader targeting the nuclear receptor binding SET structural domain protein 2 (NSD2), which inhibits tumor cell growth. This compound serves as a valuable chemical tool for investigating NSD2's function in health and disease [1]. |
| In vitro | MS159, administered at concentrations ranging from 0.5 to 10 μM over 48 hours, triggers the time- and dose-dependent degradation of NSD2 protein in 293FT cells, which is a reversible process [1]. At a concentration of 2.5 μM and after 72 hours, MS159 not only induces NSD2 degradation, but also effectively degrades IKZF1 and IKZF3 in KMS11 and H929 multiple myeloma cell lines; this degradation is facilitated by the ubiquitin-proteasome system (UPS-) and cereblon (CRBN-) mechanisms [1]. Further, sustained treatment of MS159 (2.5 μM for 8 days) significantly hampers the growth of these multiple myeloma cells, which is attributed to the induced degradation of NSD2 [1]. |
| Molecular Weight | 828.83 |
| Formula | C43H40N8O10 |
| Cas No. | 3031353-59-7 |
| Smiles | O=C(NC1=NC=C(OCCCNC(=O)CNC2=CC=CC=3C(=O)N(C(=O)C23)C4C(=O)NC(=O)CC4)C=C1)C5=CC=C(C=C5)CN(C(=O)C6=CC=C7NC(=O)COC7=C6)C8CC8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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