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Milademetan

Name: Milademetan
Brand: TargetMol
SKU: T12040
Price: 89 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12040Cas No. 1398568-47-2

Alias RAIN-32, DS3032b, DS-3032

Milademetan (DS-3032) is an orally active and potent MDM2 inhibitor with antitumor activity that induces G1 cell cycle arrest, senescence, and apoptosis.Milademetan is used in the study of acute myeloid leukemia and solid tumors.

Milademetan

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Catalog No. T12040Alias RAIN-32, DS3032b, DS-3032Cas No. 1398568-47-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$89	In Stock	-
5 mg	$179	In Stock	-
10 mg	$289	In Stock	-
25 mg	$546	In Stock	-
50 mg	$892	In Stock	-
100 mg	$1,530	In Stock	-
1 mL x 10 mM (in DMSO)	$246	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:>99.99%

Appearance:Solid

Color:White

Resource Download

COA FNMR HNMR LCMS

Product Introduction

Bioactivity

Description	Milademetan (DS-3032) is an orally active and potent MDM2 inhibitor with antitumor activity that induces G1 cell cycle arrest, senescence, and apoptosis.Milademetan is used in the study of acute myeloid leukemia and solid tumors.
In vitro	Milademetan (DS-3032) selectively induces CDKNA1, BAX, and MDM2 expression and stabilizes TP53 in neuroblastoma cells with wild-type TP53[3]. Treatment with Milademetan (DS-3032) enhances TP53 target gene expression, leading to G1 cell cycle arrest, senescence, and apoptosis[3]. In neuroblastoma cells with wild-type TP53, independent of MYCN status, Milademetan (DS-3032, 0-2000 nM) treatment selectively inhibits viability, proliferation, and migration[2].
In vivo	In mice xenografted with neuroblastoma cells possessing functional TP53, oral gavage administration of Milademetan (DS-3032) at a dose of 50 mg/kg delays tumor growth and improves overall survival[2].
Synonyms	RAIN-32, DS3032b, DS-3032

Chemical Properties

Molecular Weight	618.53
Formula	C₃₀H₃₄Cl₂FN₅O₄
Cas No.	1398568-47-2
Smiles	CC1(C)CCC2(CC1)N[C@H]([C@H](c1ccnc(Cl)c1F)[C@]21C(=O)Nc2cc(Cl)ccc12)C(=O)N[C@@H]1CC[C@H](OC1)C(N)=O
Relative Density.	1.44 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (88.92 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (1.62 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6167 mL	8.0837 mL	16.1674 mL	80.8368 mL
5 mM	0.3233 mL	1.6167 mL	3.2335 mL	16.1674 mL
10 mM	0.1617 mL	0.8084 mL	1.6167 mL	8.0837 mL
20 mM	0.0808 mL	0.4042 mL	0.8084 mL	4.0418 mL
50 mM	0.0323 mL	0.1617 mL	0.3233 mL	1.6167 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc