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Pipamperone

Name: Pipamperone
Brand: TargetMol
SKU: T12480
Price: 56 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12480Cas No. 1893-33-0

Alias R 3345, McN-JR 3345, Floropipamide

Pipamperone (McN-JR 3345) binds 5-HT2A closely as receptor.

Pipamperone

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🥰Excellent

Purity: 99.85%

Catalog No. T12480Alias R 3345, McN-JR 3345, FloropipamideCas No. 1893-33-0

Pipamperone (McN-JR 3345) binds 5-HT2A closely as receptor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$56	In Stock	In Stock
2 mg	$77	In Stock	In Stock
5 mg	$122	In Stock	In Stock
10 mg	$178	In Stock	In Stock
25 mg	$297	In Stock	In Stock
50 mg	$453	In Stock	In Stock
100 mg	$655	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$133	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.85%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Pipamperone AI Summary

Pipamperone demonstrates a broad spectrum of bioactivities. It shows high affinity in binding assays, with a binding energy measurement of 12.4 kcal mol-1, and exhibits strong inhibitory activity on membrane-bound and solubilized receptors from the rat frontal cortex, indicated by low IC50 and Ki values. It acts as an inhibitor of acid sphingomyelinase (ASM) in rat PC12 cells with an activity level of 113.2% at 10 μM and has a pKa of 8.28 and a log P of 2.02. In addition, Pipamperone inhibits delayed death in malarial parasite plastids at 15101.4 nM, Human Apurinic/apyrimidinic Endonuclease 1 (APE1) at 158.5 nM, and Marburg virus entry at 35481.3 nM. Its antiviral activities span across several viruses, including moderate activity against SARS-CoV-2, with a hit score of 0.123 and an IC50 greater than 19952.62 nM in HRCE and VERO-6 cell assays, and strong inhibition of CHIKV replication in BHK-21 cells with an activity level of 102.9% at 20 μM. Additionally, it displays high binding affinity to human DRD1, DRD3, ADRA2A, OPRM1, and HTR1A receptors, antagonist activity against TBXA2R and ADRA1A receptors, and agonist activity at ADRA1A, with no significant inhibitory activity on several other targets..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Pipamperone (McN-JR 3345) binds 5-HT2A closely as receptor.
Targets&IC50	α1-adrenoceptor:7.2 (pki), 5-HT1 receptor:5.7 (pki), D4 receptor:8.0 (pki), D2 receptor:6.7 (pki), 5-HT2C receptor:6.9 (pki), 5-HT2A receptor:8.2 (pki), pki:
Synonyms	R 3345, McN-JR 3345, Floropipamide

Chemical Properties

Molecular Weight	375.48
Formula	C₂₁H₃₀FN₃O₂
Cas No.	1893-33-0
Smiles	NC(=O)C1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)N1CCCCC1
Relative Density.	1.174g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

0.1 M HCl: 25 mg/mL (66.58 mM), Sonication is recommended.

DMSO: 100 mg/mL (266.33 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.65 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

0.1 M HCl/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6633 mL	13.3163 mL	26.6326 mL	133.1629 mL
5 mM	0.5327 mL	2.6633 mL	5.3265 mL	26.6326 mL
10 mM	0.2663 mL	1.3316 mL	2.6633 mL	13.3163 mL
20 mM	0.1332 mL	0.6658 mL	1.3316 mL	6.6581 mL
50 mM	0.0533 mL	0.2663 mL	0.5327 mL	2.6633 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0266 mL	0.1332 mL	0.2663 mL	1.3316 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc