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Anti-ERK5 Antibody (6Y531)
(Synonyms: PROTEIN KINASE, MITOGEN-ACTIVATED, 7, PRKM7, PRKM 7, OTTHUMP00000065907, OTTHUMP00000065906, MK07, Mitogen-activated protein kinase 7, Mitogen Activated Protein Kinase 7, MAPK7, MAPK 7, MAP kinase 7, Extracellular signal-regulated kinase 5, Extracellular Signal Regulated Kinase 5, ERK4, ERK 5, ERK 4, EC 2.7.11.24, BMK1 Kinase, BMK1, BMK 1 kinase, BMK 1, Big MAP kinase 1) Copy Product Info
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Synonyms: PROTEIN KINASE, MITOGEN-ACTIVATED, 7, PRKM7, PRKM 7, OTTHUMP00000065907, OTTHUMP00000065906, MK07, Mitogen-activated protein kinase 7, Mitogen Activated Protein Kinase 7, MAPK7, MAPK 7, MAP kinase 7, Extracellular signal-regulated kinase 5, Extracellular Signal Regulated Kinase 5, ERK4, ERK 5, ERK 4, EC 2.7.11.24, BMK1 Kinase, BMK1, BMK 1 kinase, BMK 1, Big MAP kinase 1
Catalog No. TMAB-00638 Copy Product Info
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Anti-ERK5 Antibody (6Y531) is a Rabbit antibody targeting ERK5. Anti-ERK5 Antibody (6Y531) can be used in WB.
Anti-ERK5 Antibody
(6Y531)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 25 µL | $154 | 7-10 days | 7-10 days | |
| 50 µL | $271 | 7-10 days | 7-10 days | |
| 100 µL | $488 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
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Antigen Details
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| Description | Anti-ERK5 Antibody (6Y531) is a Rabbit antibody targeting ERK5. Anti-ERK5 Antibody (6Y531) can be used in WB. |
| Synonyms | PROTEIN KINASE, MITOGEN-ACTIVATED, 7, PRKM7, PRKM 7, OTTHUMP00000065907, OTTHUMP00000065906, MK07, Mitogen-activated protein kinase 7, Mitogen Activated Protein Kinase 7, MAPK7, MAPK 7, MAP kinase 7, Extracellular signal-regulated kinase 5, Extracellular Signal Regulated Kinase 5, ERK4, ERK 5, ERK 4, EC 2.7.11.24, BMK1 Kinase, BMK1, BMK 1 kinase, BMK 1, Big MAP kinase 1 |
| Ig Type | IgG |
| Clone | 6Y531 |
| Reactivity | Human,Mouse (predicted:Rat) |
| Verified Activity | 1. Sample: Testis (Mouse) Lysate at 40 μg Hela (Human) Cell Lysate at 30 μg Primary: Anti-ERK5 (TMAB-00638) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 49 kDa Observed band size: 110 kDa 2. Blocking buffer: 5% NFDM/TBST Primary dilution: 1:2000 Primary incubation condition: 2 hours at room temperature Secondary: Goat Anti-Rabbit IgG H&L (HRP) Lysate: 1: MCF-7, 2: 293T, 3: NIH/3T3, 4: PC- 12 Protein loading quantity: 20 μg Exposure time: 60 s Predicted MW: 88 kDa Observed MW: 115 kDa |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Nucleus. Translocates to the nucleus upon activation. |
| Tissue Specificity | Expressed in many adult tissues. Abundant in heart, placenta, lung, kidney and skeletal muscle. Not detectable in liver. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
| Immunogen | Recombinant Protein: human ERK5 protein, around C-terminal 200aa |
| Antigen Species | Human |
| Gene Name | MAPK7 |
| Gene ID | |
| Protein Name | Mitogen-activated protein kinase 7 |
| Uniprot ID | |
| Biology Area | Neural Signal Transduction,Kinases,MAPK Pathway,Other Kinases |
| Function | Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. |
| Molecular Weight | Theoretical: 90 kDa. Actual: 110 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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