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Econazole

Name: Econazole
Brand: TargetMol
SKU: T0444
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0444Cas No. 27220-47-9

Alias (±)-Econazol

Econazole ((±)-Econazol) is an imidazole derivative that is commonly used as a topical antifungal agent.

Econazole

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Purity: 99.97%

Catalog No. T0444Alias (±)-EconazolCas No. 27220-47-9

Econazole ((±)-Econazol) is an imidazole derivative that is commonly used as a topical antifungal agent.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
200 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.97%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Econazole AI Summary

Econazole exhibits a diverse spectrum of bioactivities across various biological targets. It shows notable antifungal activity against strains such as Candida albicans, Aspergillus fumigatus, and Trichophyton asteroides with respective MIC values of 3.1 µg/mL, 3.1 µg/mL, and 0.1 µg/mL. It also targets sterol 14-alpha-demethylase with a concentration of 26.0 µM, indicating its fungicidal action, alongside inhibiting beta-lactamase and several other enzymes such as chymotrypsinogen and malate dehydrogenase. Econazole demonstrates inhibition of human Cytochrome P450 17A1 with a Ki of 325.0 nM and has notable activities against Candida parapsilosis and dermatophytes with a MIC range of 1.0 to 8.0 µg/mL. The compound exhibits antitubercular effects against Mycobacterium tuberculosis H37Rv with a MIC of 12.5 µg/mL and possesses antibacterial activity against Nocardia brasiliensis. It also affects human liver enzymes, suggesting a potential for hepatotoxicity and shows antiviral properties against SARS-CoV-2. In addition to its antifungal and antibacterial properties, Econazole has shown inhibition of several CYP450 enzymes (with an IC50 of 430.53 nM for CYP3A4) and exhibits antitumor activities with varying GI50 values across multiple human tumor cell lines. It has effects on biochemical parameters related to liver and kidney functions and demonstrates various receptor binding affinities, including activity against TRPM2, TRPM8, and HDAC6. Overall, Econazole displays a wide array of bioactivities, indicating its potential as a multi-target pharmaceutical agent, but careful consideration of its cytotoxic and enzyme-inhibitory properties is required..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Econazole ((±)-Econazol) is an imidazole derivative that is commonly used as a topical antifungal agent.
Synonyms	(±)-Econazol

Chemical Properties

Molecular Weight	381.68
Formula	C₁₈H₁₅Cl₃N₂O
Cas No.	27220-47-9
Smiles	C(CN1C=CN=C1)(OCC2=CC=C(Cl)C=C2)C3=C(Cl)C=C(Cl)C=C3
Relative Density.	1.33 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (655 mM), Sonication is recommended.

Ethanol: 5 mg/mL (13.1 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+90% Saline: 2.5 mg/mL (6.55 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6200 mL	13.1000 mL	26.2000 mL	130.9998 mL
5 mM	0.5240 mL	2.6200 mL	5.2400 mL	26.2000 mL
10 mM	0.2620 mL	1.3100 mL	2.6200 mL	13.1000 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1310 mL	0.6550 mL	1.3100 mL	6.5500 mL
50 mM	0.0524 mL	0.2620 mL	0.5240 mL	2.6200 mL
100 mM	0.0262 mL	0.1310 mL	0.2620 mL	1.3100 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc