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AF40431

Name: AF40431
Brand: TargetMol
SKU: T13530
Rating: 4.5 (1 reviews)

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Catalog No. T13530Cas No. 181125-92-8

AF40431 is the first reported small-molecule ligand of sortilin (IC50: 4.4 μM; Kd: 0.7 μM). AF40431 is bound in the neurotensin-binding site of sortilin.

AF40431

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Catalog No. T13530Cas No. 181125-92-8

AF40431 is the first reported small-molecule ligand of sortilin (IC50: 4.4 μM; Kd: 0.7 μM). AF40431 is bound in the neurotensin-binding site of sortilin.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$242	5 days	5 days
5 mg	$297	5 days	5 days
25 mg	$987	6-8 weeks	6-8 weeks
50 mg	$1,360	6-8 weeks	6-8 weeks
100 mg	$1,860	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	AF40431 is the first reported small-molecule ligand of sortilin (IC50: 4.4 μM; Kd: 0.7 μM). AF40431 is bound in the neurotensin-binding site of sortilin.
Targets&IC50	Sortilin:4.4 µM (sortilin) Kd: 0.7 µM (IC50)

Chemical Properties

Molecular Weight	319.35
Formula	C₁₇H₂₁NO₅
Cas No.	181125-92-8
Smiles	CC(C)C[C@H](NCc1c(O)ccc2c(C)cc(=O)oc12)C(O)=O
Relative Density.	1.261 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (78.28 mM), when pH is adjusted to 1 with TFA. Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1314 mL	15.6568 mL	31.3136 mL	156.5680 mL
5 mM	0.6263 mL	3.1314 mL	6.2627 mL	31.3136 mL
10 mM	0.3131 mL	1.5657 mL	3.1314 mL	15.6568 mL
20 mM	0.1566 mL	0.7828 mL	1.5657 mL	7.8284 mL
50 mM	0.0626 mL	0.3131 mL	0.6263 mL	3.1314 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc