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AF40431

Name: AF40431
Brand: TargetMol
SKU: T13530
Rating: 4.5 (1 reviews)

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Catalog No. T13530Cas No. 181125-92-8

AF40431 is the first reported small-molecule ligand of sortilin (IC50: 4.4 μM; Kd: 0.7 μM). AF40431 is bound in the neurotensin-binding site of sortilin.

AF40431

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Catalog No. T13530Cas No. 181125-92-8

AF40431 is the first reported small-molecule ligand of sortilin (IC50: 4.4 μM; Kd: 0.7 μM). AF40431 is bound in the neurotensin-binding site of sortilin.

Pack Size	Price	Availability
2 mg	$242	5 days
5 mg	$297	5 days
25 mg	$987	6-8 weeks
50 mg	$1,360	6-8 weeks
100 mg	$1,860	6-8 weeks

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Product Introduction

Bioactivity

Description	AF40431 is the first reported small-molecule ligand of sortilin (IC50: 4.4 μM; Kd: 0.7 μM). AF40431 is bound in the neurotensin-binding site of sortilin.
Targets&IC50	Sortilin:4.4 µM (sortilin) Kd: 0.7 µM (IC50)

Chemical Properties

Molecular Weight	319.35
Formula	C₁₇H₂₁NO₅
Cas No.	181125-92-8
Relative Density.	1.261 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (78.28 mM), when pH is adjusted to 1 with TFA. Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1314 mL	15.6568 mL	31.3136 mL	156.5680 mL
5 mM	0.6263 mL	3.1314 mL	6.2627 mL	31.3136 mL
10 mM	0.3131 mL	1.5657 mL	3.1314 mL	15.6568 mL
20 mM	0.1566 mL	0.7828 mL	1.5657 mL	7.8284 mL
50 mM	0.0626 mL	0.3131 mL	0.6263 mL	3.1314 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc