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Valacyclovir hydrochloride

Name: Valacyclovir hydrochloride
Brand: TargetMol
SKU: T1087
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1087Cas No. 124832-27-5

Alias Valaciclovir hydrochloride, Valaciclovir HCl

Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an acyclovir prodrug that, upon metabolism, inhibits viral DNA replication.

Valacyclovir hydrochloride

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Purity: 99.88%

Catalog No. T1087Alias Valaciclovir hydrochloride, Valaciclovir HClCas No. 124832-27-5

Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an acyclovir prodrug that, upon metabolism, inhibits viral DNA replication.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$32	In Stock	In Stock
50 mg	$56	In Stock	In Stock
100 mg	$98	In Stock	In Stock
500 mg	$197	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$35	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.88%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Valacyclovir hydrochloride AI Summary

Valacyclovir hydrochloride exhibits a broad spectrum of biological activities including the induction of DNA re-replication in normal breast cells and colon adenocarcinoma cells with varying potencies. It specifically inhibits human tyrosyl-DNA phosphodiesterase 1, USP1/UAF1, and PTHR in different cellular environments, both with and without camptothecin (CPT). Additionally, it displays potential to block the entry of the Ebola virus and inhibits sodium fluorescein uptake in OATP1B3 and OATP1B1-transfected CHO cells by 80.91% and 68.57% respectively at 10 μM. In terms of gastrointestinal absorption, Valacyclovir hydrochloride demonstrates significant drug uptake in mouse jejunum (82.0%) and varying permeability across different cell types and pH conditions. It also shows good oral bioavailability in rats (54.0% at 25 mg/kg), with low chemical stability (<5.0%). The compound exhibits no significant inhibition of human BSEP, MRP2, MRP3, and MRP4 transporters with IC50 values greater than 133,000 nM, indicating minimal bioactivity against these targets. Despite assessing antiviral activity against SARS-CoV-2 in different assays, the compound generally shows low to minimal inhibition rates, indicating limited effectiveness against the virus under tested conditions. Moreover, Valacyclovir hydrochloride demonstrates antifungal activity against Candida albicans (3.14% inhibition) and antibacterial activity against various bacteria, including Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus MRSA, with inhibition rates ranging from 6.23% to 17.42%. However, its activity against Cryptococcus neoformans H99 shows a negative inhibition rate (-5.07%). Overall, Valacyclovir hydrochloride possesses multiple bioactive properties with potential implications for treating cancer, viral infections including Ebola, certain bacterial infections, and fungal diseases, while also exhibiting specific inhibitory actions on drug transport processes..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an acyclovir prodrug that, upon metabolism, inhibits viral DNA replication.
Targets&IC50	HSV1:2.9 μg/mL (IC50)
In vitro	In male CD rats, Valaciclovir was absorbed orally, efficiently metabolized and rapidly distributed.
In vivo	Valaciclovir is the L-valine ester of aciclovir, the absorption of which occurs in the intestinal lumen and is converted to the L-valine ester of aciclovir.Valaciclovir inhibits the uptake of dipeptide transporter protein substrates, e.g., cephalosporin.
Synonyms	Valaciclovir hydrochloride, Valaciclovir HCl

Chemical Properties

Molecular Weight	360.80
Formula	C₁₃H₂₀N₆O₄·HCl
Cas No.	124832-27-5
Smiles	Cl.CC(C)[C@H](N)C(=O)OCCOCn1cnc2c1nc(N)[nH]c2=O
Relative Density.	1.55g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20.4 mg/mL (56.54 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.54 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7716 mL	13.8581 mL	27.7162 mL	138.5809 mL
5 mM	0.5543 mL	2.7716 mL	5.5432 mL	27.7162 mL
10 mM	0.2772 mL	1.3858 mL	2.7716 mL	13.8581 mL
20 mM	0.1386 mL	0.6929 mL	1.3858 mL	6.9290 mL
50 mM	0.0554 mL	0.2772 mL	0.5543 mL	2.7716 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc