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Lats-IN-1

Name: Lats-IN-1
Brand: TargetMol
SKU: T9053
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9053Cas No. 1424635-83-5

Lats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.

Lats-IN-1

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Purity: 99.79%

Catalog No. T9053Cas No. 1424635-83-5

Lats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	In Stock	In Stock
2 mg	$67	In Stock	In Stock
5 mg	$107	In Stock	In Stock
10 mg	$170	In Stock	In Stock
25 mg	$326	In Stock	In Stock
50 mg	$438	In Stock	In Stock
100 mg	$623	In Stock	In Stock
200 mg	$887	-	In Stock
1 mL x 10 mM (in DMSO)	$120	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.79%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Lats-IN-1 AI Summary

Lats-IN-1 demonstrates a decrease in cell viability across different cell types, including HEK293T, U2OS, and human fibroblasts, as indicated by the reduction in growth rates observed in the assays. This suggests a potential bioactivity of inhibiting cell growth or inducing cell death..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Lats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.

Chemical Properties

Molecular Weight	334.39
Formula	C₁₈H₁₄N₄OS
Cas No.	1424635-83-5
Smiles	O=C(\N=c1/sccn1Cc1ccccc1)c1c[nH]c2ncccc12
Relative Density.	1.36 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 83.33 mg/mL (249.2 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (9.87 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9905 mL	14.9526 mL	29.9052 mL	149.5260 mL
5 mM	0.5981 mL	2.9905 mL	5.9810 mL	29.9052 mL
10 mM	0.2991 mL	1.4953 mL	2.9905 mL	14.9526 mL
20 mM	0.1495 mL	0.7476 mL	1.4953 mL	7.4763 mL
50 mM	0.0598 mL	0.2991 mL	0.5981 mL	2.9905 mL
100 mM	0.0299 mL	0.1495 mL	0.2991 mL	1.4953 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc