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UC-781

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Catalog No. T29037Cas No. 178870-32-1
Alias UC781, UC 781, NSC 675186

UC-781 (NSC-675186) is a potent and selective inhibitor of human immunodeficiency virus HIV-1 non-nucleoside reverse transcriptase (NNRTI) I with a C50 value of 5 nM.UC-781 exhibits both antiviral activity and drug resistance.UC-781 is in a stable state, and is unaffected by lower pH or varying temperatures.

UC-781

UC-781

😃Good
Catalog No. T29037Alias UC781, UC 781, NSC 675186Cas No. 178870-32-1
UC-781 (NSC-675186) is a potent and selective inhibitor of human immunodeficiency virus HIV-1 non-nucleoside reverse transcriptase (NNRTI) I with a C50 value of 5 nM.UC-781 exhibits both antiviral activity and drug resistance.UC-781 is in a stable state, and is unaffected by lower pH or varying temperatures.
Pack SizePriceAvailabilityQuantity
1 mg$1916-8 weeks
25 mg$1,1306-8 weeks
50 mg$1,4806-8 weeks
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Product Introduction

Bioactivity
Description
UC-781 (NSC-675186) is a potent and selective inhibitor of human immunodeficiency virus HIV-1 non-nucleoside reverse transcriptase (NNRTI) I with a C50 value of 5 nM.UC-781 exhibits both antiviral activity and drug resistance.UC-781 is in a stable state, and is unaffected by lower pH or varying temperatures.
Targets&IC50
HIV-1:0.005 μM
In vitro
UC-781 (0.05, 0.2, and 0.5 % UC-781 supplemented gel; 10 days) is released from the gel formulation and clears HIV-1 from CEM cells [1].
UC-781 (3.75 -30 μM) inhibits the growth of Bacillus cereus (approximately 50%).[1]
UC-781 inhibits HIV-1 (IIIB) activity in CEM T cells (EC50=6 nM; IC50=23 nM). UC-781 inhibits HIV activity in monocyte-derived dendritic cells (MO-DCs) and autologous CD4+ T cells with EC50 values of 550 nM and 1588 nM, respectively.[2]
UC-781 (1000 nM; 24 h) effectively prevents or blocks HIV infection of monocyte-derived dendritic cells and autologous CD4+ T cells.[2]
UC-781 (0.001-1000 µM; 2 h) inhibits viral transfer and infection of cervical explants with HIV-1BaL.[4]
In vivo
UC-781 (100 µl 5% UC-781 supplemented gel; intravaginally; once daily for 10 days; Female rabbit) is released from the gel formulation, exhibiting low toxicity to normal tissues in female rabbits with no significant increase in inflammatory cells.[1]
AliasUC781, UC 781, NSC 675186
Chemical Properties
Molecular Weight335.85
FormulaC17H18ClNO2S
Cas No.178870-32-1
SmilesN(C(=S)C1=C(C)OC=C1)C2=CC(OCC=C(C)C)=C(Cl)C=C2
Relative Density.1.240 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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