UC-781 (NSC-675186) is a potent and selective inhibitor of human immunodeficiency virus HIV-1 non-nucleoside reverse transcriptase (NNRTI) I with a C50 value of 5 nM.UC-781 exhibits both antiviral activity and drug resistance.UC-781 is in a stable state, and is unaffected by lower pH or varying temperatures.

HIV-1:0.005 μM

UC-781 (0.05, 0.2, and 0.5 % UC-781 supplemented gel; 10 days) is released from the gel formulation and clears HIV-1 from CEM cells [1].
UC-781 (3.75 -30 μM) inhibits the growth of Bacillus cereus (approximately 50%).[1]
UC-781 inhibits HIV-1 (IIIB) activity in CEM T cells (EC50=6 nM; IC50=23 nM). UC-781 inhibits HIV activity in monocyte-derived dendritic cells (MO-DCs) and autologous CD4+ T cells with EC50 values of 550 nM and 1588 nM, respectively.[2]
UC-781 (1000 nM; 24 h) effectively prevents or blocks HIV infection of monocyte-derived dendritic cells and autologous CD4+ T cells.[2]
UC-781 (0.001-1000 µM; 2 h) inhibits viral transfer and infection of cervical explants with HIV-1BaL.[4]

UC-781 (100 µl 5% UC-781 supplemented gel; intravaginally; once daily for 10 days; Female rabbit) is released from the gel formulation, exhibiting low toxicity to normal tissues in female rabbits with no significant increase in inflammatory cells.[1]