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N-Acetyl-L-cysteine ethyl ester

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Catalog No. T41285Cas No. 59587-09-6
Alias N-Acetylcysteine ethyl ester, NACET

N-Acetyl-L-cysteine ethyl ester (NACET) is a derivative of the amino acid L-cysteine. NACET has been shown to exhibit diverse biochemical and physiological effects, including inhibition of protein synthesis, inhibition of DNA replication, and induction of apoptosis. Additionally, it has demonstrated anti-inflammatory, antioxidant, and anti-cancer activity.

N-Acetyl-L-cysteine ethyl ester

N-Acetyl-L-cysteine ethyl ester

😃Good
Purity: 97.1%
Catalog No. T41285Alias N-Acetylcysteine ethyl ester, NACETCas No. 59587-09-6
N-Acetyl-L-cysteine ethyl ester (NACET) is a derivative of the amino acid L-cysteine. NACET has been shown to exhibit diverse biochemical and physiological effects, including inhibition of protein synthesis, inhibition of DNA replication, and induction of apoptosis. Additionally, it has demonstrated anti-inflammatory, antioxidant, and anti-cancer activity.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$30-In Stock
10 mg$40-In Stock
25 mg$71-In Stock
50 mg$113-In Stock
100 mg$198-In Stock
200 mg$298-In Stock
1 mL x 10 mM (in DMSO)$44-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:97.1%
Appearance:Solid
Color:White
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
N-Acetyl-L-cysteine ethyl ester (NACET) is a derivative of the amino acid L-cysteine. NACET has been shown to exhibit diverse biochemical and physiological effects, including inhibition of protein synthesis, inhibition of DNA replication, and induction of apoptosis. Additionally, it has demonstrated anti-inflammatory, antioxidant, and anti-cancer activity.
In vitro
Under concomitant oxidative stress induced by 2 mM H2O2, N-Acetyl-L-cysteine ethyl ester (NACET) showed strong and significant protective effect on RPE cells when the concentration was 0.4 mM. Moreover, NACET treatment also resulted in an enhanced protective effect when RPE cells were stressed by the organic ROS generator peroxide tert-Butyl hydroperoxide (t-BOOH).NACET significantly increased both intracellular GSH and cysteine at 0.2 and 1 mM concentrations, respectively, as well as extracellular total GSH[2].
SynonymsN-Acetylcysteine ethyl ester, NACET
Chemical Properties
Molecular Weight191.25
FormulaC7H13NO3S
Cas No.59587-09-6
SmilesCCOC(=O)[C@H](CS)NC(C)=O
Relative Density.1.138 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 45 mg/mL (235.29 mM), Sonication is recommended.
H2O: 90 mg/mL (470.59 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (5.23 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM5.2288 mL26.1438 mL52.2876 mL261.4379 mL
5 mM1.0458 mL5.2288 mL10.4575 mL52.2876 mL
10 mM0.5229 mL2.6144 mL5.2288 mL26.1438 mL
20 mM0.2614 mL1.3072 mL2.6144 mL13.0719 mL
50 mM0.1046 mL0.5229 mL1.0458 mL5.2288 mL
100 mM0.0523 mL0.2614 mL0.5229 mL2.6144 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

N-Acetyl-L-cysteine ethyl esterAntioxidant
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