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Oxidopamine hydrochloride

Name: Oxidopamine hydrochloride
Brand: TargetMol
SKU: T12352
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12352Cas No. 28094-15-7

Alias 6-OHDA hydrochloride, 6-Hydroxydopamine hydrochloride

Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is a widely used neurotoxin and an antagonist of the neurotransmitter dopamine. It selectively destroys dopaminergic neurons, promotes COX-2 activation, induces PGE2 synthesis, and stimulates the secretion of the inflammatory cytokine IL-1β. It is commonly used to establish animal models of Parkinson’s disease (PD).

Oxidopamine hydrochloride

🥰Excellent

Purity: 99.85%

Catalog No. T12352Alias 6-OHDA hydrochloride, 6-Hydroxydopamine hydrochlorideCas No. 28094-15-7

Pack Size	Price	Availability
5 mg	$39	In Stock
10 mg	$59	In Stock
25 mg	$105	In Stock
50 mg	$178	In Stock
100 mg	$272	In Stock

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Purity:99.85%

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Product Introduction

Bioactivity

Description	Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is a widely used neurotoxin and an antagonist of the neurotransmitter dopamine. It selectively destroys dopaminergic neurons, promotes COX-2 activation, induces PGE2 synthesis, and stimulates the secretion of the inflammatory cytokine IL-1β. It is commonly used to establish animal models of Parkinson’s disease (PD).
Synonyms	6-OHDA hydrochloride, 6-Hydroxydopamine hydrochloride

Chemical Properties

Molecular Weight	205.64
Formula	C₈H₁₂ClNO₃
Cas No.	28094-15-7
Smiles	Cl.NCCc1cc(O)c(O)cc1O
Relative Density.	no data available

Storage & Solubility Information

Storage

store under nitrogen | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 62.49 mg/mL (303.88 mM), Sonication and heating are recommended.The compound is unstable in solution, please use soon.

DMSO: 62.49 mg/mL (303.88 mM), Sonication and heating are recommended.The compound is unstable in solution, please use soon.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.73 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8629 mL	24.3143 mL	48.6287 mL	243.1434 mL
5 mM	0.9726 mL	4.8629 mL	9.7257 mL	48.6287 mL
10 mM	0.4863 mL	2.4314 mL	4.8629 mL	24.3143 mL
20 mM	0.2431 mL	1.2157 mL	2.4314 mL	12.1572 mL
50 mM	0.0973 mL	0.4863 mL	0.9726 mL	4.8629 mL
100 mM	0.0486 mL	0.2431 mL	0.4863 mL	2.4314 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc