Shopping Cart

Your shopping cart is currently empty

Oxidopamine hydrochloride

Name: Oxidopamine hydrochloride
Brand: TargetMol
SKU: T12352
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T12352Cas No. 28094-15-7

Alias 6-OHDA hydrochloride, 6-Hydroxydopamine hydrochloride

Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is a widely used neurotoxin and an antagonist of the neurotransmitter dopamine. It selectively destroys dopaminergic neurons, promotes COX-2 activation, induces PGE2 synthesis, and stimulates the secretion of the inflammatory cytokine IL-1β. It is commonly used to establish animal models of Parkinson’s disease (PD).

Oxidopamine hydrochloride

Copy Product Info

🥰Excellent

Purity: 99.85%

Catalog No. T12352Alias 6-OHDA hydrochloride, 6-Hydroxydopamine hydrochlorideCas No. 28094-15-7

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$39	In Stock	-
10 mg	$59	In Stock	-
25 mg	$105	In Stock	In Stock
50 mg	$178	In Stock	-
100 mg	$272	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.85%

Color:White to Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Oxidopamine hydrochloride AI Summary

Oxidopamine hydrochloride exhibits multiple bioactivities across various biological targets and systems. It is effective in inhibiting plant growth by reducing the elongation of pinto bean plants' second internode by 26.0% at both 50 µg and 150 µg concentrations over 4 days. In medical and biological contexts, it demonstrates potent inhibition of several targets such as Menin-MLL interaction (relevant to MLL-related leukemias), RECQ1, HSD17B4, JMJD2E, TDP1, and Tau Fibril Formation. It affects key pathways including the ERK signaling pathway and inhibits a range of tumor cell lines such as MDA-N Breast, SN12C Renal, ACHN Renal, UO-31 Renal, DU-145 Prostate, SK-MEL-5 Melanoma, SF-539 Central Nervous System, and K-562 Leukemia. Additionally, Oxidopamine hydrochloride displays antiviral properties by inhibiting viral entry of pathogens such as Lassa, Marburg, Ebola, Hepatitis C, and SARS-CoV-2. It inhibits SARS-CoV-2 3CL-Pro protease by 55.73% at 20 µM and reduces SARS-CoV-2 induced cytotoxicity in both VERO-6 and Caco-2 cells. It also impacts sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells at a 10 µM concentration. In bacterial systems, it significantly inhibits Escherichia coli GroEL/GroES proteins' function, and it shows bioactivity as an AGO2 inhibitor with an IC50 of 1610.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is a widely used neurotoxin and an antagonist of the neurotransmitter dopamine. It selectively destroys dopaminergic neurons, promotes COX-2 activation, induces PGE2 synthesis, and stimulates the secretion of the inflammatory cytokine IL-1β. It is commonly used to establish animal models of Parkinson’s disease (PD).
Synonyms	6-OHDA hydrochloride, 6-Hydroxydopamine hydrochloride

Chemical Properties

Molecular Weight	205.64
Formula	C₈H₁₂ClNO₃
Cas No.	28094-15-7
Smiles	Cl.NCCc1cc(O)c(O)cc1O
Relative Density.	no data available

Storage & Solubility Information

Storage

store under nitrogen,The compound is unstable in solution. Please use soon | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 62.49 mg/mL (303.88 mM), Sonication and heating are recommended.The compound is unstable in solution, please use soon.

DMSO: 62.49 mg/mL (303.88 mM), Sonication and heating are recommended.The compound is unstable in solution, please use soon.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.73 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8629 mL	24.3143 mL	48.6287 mL	243.1434 mL
5 mM	0.9726 mL	4.8629 mL	9.7257 mL	48.6287 mL
10 mM	0.4863 mL	2.4314 mL	4.8629 mL	24.3143 mL
20 mM	0.2431 mL	1.2157 mL	2.4314 mL	12.1572 mL
50 mM	0.0973 mL	0.4863 mL	0.9726 mL	4.8629 mL
100 mM	0.0486 mL	0.2431 mL	0.4863 mL	2.4314 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc