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1-Hydroxyanthraquinone

Name: 1-Hydroxyanthraquinone
Brand: TargetMol
SKU: T37101
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T37101Cas No. 129-43-1

1-Hydroxyanthraquinone is an anthraquinone that has been found in Morinda officinalis and has genotoxic and carcinogenic activities. 1-Hydroxyanthraquinone generates strong DNA repair response.

1-Hydroxyanthraquinone

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Purity: 99.56%

Catalog No. T37101Cas No. 129-43-1

1-Hydroxyanthraquinone is an anthraquinone that has been found in Morinda officinalis and has genotoxic and carcinogenic activities. 1-Hydroxyanthraquinone generates strong DNA repair response.

Pack Size	Price	USA Warehouse	Global Warehouse
1 g	$29	-	In Stock
5 g	$68	-	In Stock
10 g	$98	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.56%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	1-Hydroxyanthraquinone is an anthraquinone that has been found in Morinda officinalis and has genotoxic and carcinogenic activities. 1-Hydroxyanthraquinone generates strong DNA repair response.
In vitro	1-Hydroxyanthraquinone (5 and 500 μM) increases the percentage of isolated rat hepatocytes undergoing unscheduled DNA synthesis, indicating genotoxic activity[2].
In vivo	Dietary administration of 1-Hydroxyanthraquinone (1%) induces formation of cecum and colon adenocarcinomas, as well as hepatocellular carcinomas, in rats[2].

Chemical Properties

Molecular Weight	224.21
Formula	C₁₄H₈O₃
Cas No.	129-43-1
Smiles	OC1=CC=CC2=C1C(=O)C1=C(C=CC=C1)C2=O
Relative Density.	1.423g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Chloroform: 30 mg/mL (133.8 mM), Sonication is recommended.

DMSO: 3.93 mg/mL (17.53 mM), Sonication is recommended.

Solution Preparation Table

DMSO/Chloroform

	1mg	5mg	10mg	50mg
1 mM	4.4601 mL	22.3005 mL	44.6010 mL	223.0052 mL
5 mM	0.8920 mL	4.4601 mL	8.9202 mL	44.6010 mL
10 mM	0.4460 mL	2.2301 mL	4.4601 mL	22.3005 mL

Chloroform

	1mg	5mg	10mg	50mg
20 mM	0.2230 mL	1.1150 mL	2.2301 mL	11.1503 mL
50 mM	0.0892 mL	0.4460 mL	0.8920 mL	4.4601 mL
100 mM	0.0446 mL	0.2230 mL	0.4460 mL	2.2301 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc