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Tetracaine hydrochloride

Name: Tetracaine hydrochloride
Brand: TargetMol
SKU: T1198
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1198Cas No. 136-47-0

Alias Tetracaine HCl, Amethocalne HCl, Amethocaine hydrochloride

Tetracaine hydrochloride (Amethocalne HCl) (Pontocaine), a potent local anaesthetic, is a channel function allosteric inhibitor. It is primarily used as an antipruritic and topically in ophthalmology, and it has been used for surface and spinal anesthesia.

Tetracaine hydrochloride

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Purity: 99.94%

Catalog No. T1198Alias Tetracaine HCl, Amethocalne HCl, Amethocaine hydrochlorideCas No. 136-47-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
200 mg	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.94%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Tetracaine hydrochloride AI Summary

Tetracaine hydrochloride exhibits a wide range of bioactivities. It demonstrates potency in inhibiting the proliferation of Plasmodium falciparum lines 3D7, GB4, and D10, and modulates various cellular activities such as Lamin A splicing, erasure of genomic imprints, and inducing DNA re-replication. Additionally, it inhibits several enzymes and proteins, including Human Jumonji Domain Containing 2E, Rab9 Promoter, APE1, N370S glucocerebrosidase, BAZ2B, TGF-b, Histone Lysine Methyltransferase G9a, Bloom's syndrome helicase, 15-hLO-2, and human tyrosyl-DNA phosphodiesterase 1 (TDP1). It blocks the entry of Marburg and Ebola viruses and displays potencies ranging from nanomolar to micromolar concentrations. The compound has been evaluated using the Drug Induced Liver Injury Prediction System (DILIps) validation dataset and is identified as DILI negative based on Pfizer data. At an equimolar substrate-inhibitor concentration of 10 µM, Tetracaine hydrochloride inhibits sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells with an inhibitory activity of 88.3% and 61.91%, respectively. Tetracaine hydrochloride also shows significant antiviral activities. In Vero E6 cells infected with SARS-CoV-2 (strain BavPat1), it exhibits an inhibition index of 0.4749 at an MOI of 0.002 after 72 hours. It inhibits SARS-CoV-2-induced cytotoxicity in Caco-2 cells by 18.71% at a concentration of 10 µM after 48 hours and inhibits SARS-CoV-2 3CL-Pro protease activity by 29.79% at a concentration of 20 µM as determined through a FRET response. Additionally, it demonstrates inhibition of SARS-CoV-2-induced cytotoxicity in VERO-6 cells by 0.04% at 10 µM after 48 hours exposure..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Tetracaine hydrochloride (Amethocalne HCl) (Pontocaine), a potent local anaesthetic, is a channel function allosteric inhibitor. It is primarily used as an antipruritic and topically in ophthalmology, and it has been used for surface and spinal anesthesia.
Synonyms	Tetracaine HCl, Amethocalne HCl, Amethocaine hydrochloride

Chemical Properties

Molecular Weight	300.82
Formula	C₁₅H₂₅ClN₂O₂
Cas No.	136-47-0
Smiles	Cl.CCCCNc1ccc(cc1)C(=O)OCCN(C)C
Relative Density.	1.1279 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 28 mg/mL (93.08 mM), Sonication is recommended.

H2O: 55 mg/mL (182.83 mM), Sonication is recommended.

DMSO: 40 mg/mL (132.97 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.3242 mL	16.6212 mL	33.2425 mL	166.2124 mL
5 mM	0.6648 mL	3.3242 mL	6.6485 mL	33.2425 mL
10 mM	0.3324 mL	1.6621 mL	3.3242 mL	16.6212 mL
20 mM	0.1662 mL	0.8311 mL	1.6621 mL	8.3106 mL
50 mM	0.0665 mL	0.3324 mL	0.6648 mL	3.3242 mL

DMSO/H2O

	1mg	5mg	10mg	50mg
100 mM	0.0332 mL	0.1662 mL	0.3324 mL	1.6621 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc